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- W2028622487 abstract "Ciclosporin is clinically effective in a variety of inflammatory skin diseases. We have therefore studied the effects of the drug on cutaneous inflammation in mice. Ciclosporin inhibited the inflammatory response to 12-O-tetradecanoylphorbol-13-acetate (TPA) and to the contact sensitising agent oxazolone when applied topically to mouse skin. The drug had no effect on arachidonic acid-induced inflammation. The protein synthesis inhibitor cycloheximide showed a similar profile of activity. Ciclosporin, like actinomycin D but unlike cycloheximide, was only effective in inhibiting the inflammatory response to TPA if given 0.5 h before, but not 2 h, after TPA. These results suggest that the anti-inflammatory activity of ciclosporin in the skin is due to an effect on the production of proinflammatory proteins." @default.
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- W2028622487 date "1989-01-01" @default.
- W2028622487 modified "2023-09-25" @default.
- W2028622487 title "Effects of Ciclosporin and Protein Synthesis Inhibitors on Cutaneous Inflammation in Mouse Skin" @default.
- W2028622487 doi "https://doi.org/10.1159/000210799" @default.
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