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- W2028626977 endingPage "399" @default.
- W2028626977 startingPage "389" @default.
- W2028626977 abstract "Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by peripheral cytopenias and ineffective hematopoiesis. MDS is an example of an age-related malignancy and its increasing prevalence and incidence can be attributed to a greater life expectancy in developed countries. Although frequently encountered in hematology/oncology clinics, MDS may constitute a diagnostic challenge especially with equivocal bone marrow morphology. Certain syndromes of bone marrow failure (BMF) may mimic MDS and formulating a correct diagnosis is vital for adequate prognostication as well as therapeutic approaches. Metaphase karyotyping (MK) is a very important diagnostic tool and marker of prognosis and can be an indicator of response to certain therapies. Unfortunately, chromosomal abnormalities may only be found in approximately 50 % of patients with MDS. In this review, we discuss the diagnostic approaches to patients with pancytopenia with a particular focus on the growing number of somatic mutations through new molecular testing." @default.
- W2028626977 created "2016-06-24" @default.
- W2028626977 creator A5035609080 @default.
- W2028626977 creator A5064140300 @default.
- W2028626977 date "2014-07-31" @default.
- W2028626977 modified "2023-10-04" @default.
- W2028626977 title "I Walk the Line: How to Tell MDS From Other Bone Marrow Failure Conditions" @default.
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