Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028630798> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2028630798 endingPage "1560" @default.
- W2028630798 startingPage "1555" @default.
- W2028630798 abstract "To evaluate the pharmacokinetics of L-threonate after single or multiple oral administrations and its safety profile in healthy Chinese volunteers.This was an open-label, single- and multiple-dose study. The subjects were assigned to receive a single dose, 675, 2025, or 4050 mg, of calcium L-threonate (n=12) or repeated doses of 2025 mg twice daily for 4 d (n=12). Serial plasma and urine samples were analyzed with HPLC-MS/MS. Pharmacokinetic parameters of L-threonate were calculated using non-compartmental analysis with WinNonlin software.In the single dose group, C(max) reached at 2.0 h and the mean t(1/2) was approximately 2.5 h. Area under curve (AUC) and C(max) increased with dose escalation, but dose proportionality was not observed over the range of 675 to 4050 mg. AUC and C(max) in the fasted subjects were lower compared with those in the non-fasted subjects. Cumulative urinary excretion of L-threonate over 24 h represented 5.9% of the administered dose with a mean Cl/r of 0.8 L/h. In the multiple-dose study, no accumulation appeared upon repeated doses of 2025 mg twice daily for 4 d. There were no serious adverse events that occurred during this study.Calcium L-threonate was well tolerated in healthy Chinese subjects, with no pattern of dose-related adverse events. Plasma exposure increased with dose escalation, but linear pharmacokinetics were not observed over the studied doses. L-threonate was absorbed rapidly, and its absorption was enhanced by food intake. No systemic accumulation appeared after repeated administrations." @default.
- W2028630798 created "2016-06-24" @default.
- W2028630798 creator A5034804463 @default.
- W2028630798 creator A5076668920 @default.
- W2028630798 creator A5078736303 @default.
- W2028630798 date "2011-10-10" @default.
- W2028630798 modified "2023-10-18" @default.
- W2028630798 title "Pharmacokinetics and safety of calcium L-threonate in healthy volunteers after single and multiple oral administrations" @default.
- W2028630798 cites W1692555477 @default.
- W2028630798 cites W18924068 @default.
- W2028630798 cites W1969710339 @default.
- W2028630798 cites W1985184665 @default.
- W2028630798 cites W1990187444 @default.
- W2028630798 cites W1991764276 @default.
- W2028630798 cites W2006388001 @default.
- W2028630798 cites W2013015810 @default.
- W2028630798 cites W2028457075 @default.
- W2028630798 cites W2039802058 @default.
- W2028630798 cites W2060736241 @default.
- W2028630798 cites W2075108741 @default.
- W2028630798 cites W2079756354 @default.
- W2028630798 cites W2091596613 @default.
- W2028630798 cites W2128986278 @default.
- W2028630798 cites W2142051176 @default.
- W2028630798 cites W2147052905 @default.
- W2028630798 doi "https://doi.org/10.1038/aps.2011.138" @default.
- W2028630798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4010217" @default.
- W2028630798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21986570" @default.
- W2028630798 hasPublicationYear "2011" @default.
- W2028630798 type Work @default.
- W2028630798 sameAs 2028630798 @default.
- W2028630798 citedByCount "7" @default.
- W2028630798 countsByYear W20286307982012 @default.
- W2028630798 countsByYear W20286307982016 @default.
- W2028630798 countsByYear W20286307982017 @default.
- W2028630798 countsByYear W20286307982019 @default.
- W2028630798 countsByYear W20286307982020 @default.
- W2028630798 countsByYear W20286307982022 @default.
- W2028630798 crossrefType "journal-article" @default.
- W2028630798 hasAuthorship W2028630798A5034804463 @default.
- W2028630798 hasAuthorship W2028630798A5076668920 @default.
- W2028630798 hasAuthorship W2028630798A5078736303 @default.
- W2028630798 hasBestOaLocation W20286307981 @default.
- W2028630798 hasConcept C10146269 @default.
- W2028630798 hasConcept C112705442 @default.
- W2028630798 hasConcept C121332964 @default.
- W2028630798 hasConcept C125287762 @default.
- W2028630798 hasConcept C126322002 @default.
- W2028630798 hasConcept C197934379 @default.
- W2028630798 hasConcept C24890656 @default.
- W2028630798 hasConcept C2780026642 @default.
- W2028630798 hasConcept C519063684 @default.
- W2028630798 hasConcept C71924100 @default.
- W2028630798 hasConcept C76318530 @default.
- W2028630798 hasConcept C98274493 @default.
- W2028630798 hasConceptScore W2028630798C10146269 @default.
- W2028630798 hasConceptScore W2028630798C112705442 @default.
- W2028630798 hasConceptScore W2028630798C121332964 @default.
- W2028630798 hasConceptScore W2028630798C125287762 @default.
- W2028630798 hasConceptScore W2028630798C126322002 @default.
- W2028630798 hasConceptScore W2028630798C197934379 @default.
- W2028630798 hasConceptScore W2028630798C24890656 @default.
- W2028630798 hasConceptScore W2028630798C2780026642 @default.
- W2028630798 hasConceptScore W2028630798C519063684 @default.
- W2028630798 hasConceptScore W2028630798C71924100 @default.
- W2028630798 hasConceptScore W2028630798C76318530 @default.
- W2028630798 hasConceptScore W2028630798C98274493 @default.
- W2028630798 hasIssue "12" @default.
- W2028630798 hasLocation W20286307981 @default.
- W2028630798 hasLocation W20286307982 @default.
- W2028630798 hasLocation W20286307983 @default.
- W2028630798 hasLocation W20286307984 @default.
- W2028630798 hasOpenAccess W2028630798 @default.
- W2028630798 hasPrimaryLocation W20286307981 @default.
- W2028630798 hasRelatedWork W1984705561 @default.
- W2028630798 hasRelatedWork W2009246547 @default.
- W2028630798 hasRelatedWork W2318353920 @default.
- W2028630798 hasRelatedWork W2322623919 @default.
- W2028630798 hasRelatedWork W2348302343 @default.
- W2028630798 hasRelatedWork W2378109603 @default.
- W2028630798 hasRelatedWork W297699154 @default.
- W2028630798 hasRelatedWork W4253007265 @default.
- W2028630798 hasRelatedWork W928645210 @default.
- W2028630798 hasRelatedWork W1989789688 @default.
- W2028630798 hasVolume "32" @default.
- W2028630798 isParatext "false" @default.
- W2028630798 isRetracted "false" @default.
- W2028630798 magId "2028630798" @default.
- W2028630798 workType "article" @default.