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- W2028638156 endingPage "318" @default.
- W2028638156 startingPage "307" @default.
- W2028638156 abstract "Abnormal fatty acid metabolism and dyslipidemia play an intimate role in the pathogenesis of metabolic syndrome and cardiovascular diseases. The availability of glucose and insulin predominate as upstream regulatory elements that operate through a collection of transcription factors to partition lipids toward anabolic pathways. The unraveling of the details of these cellular events has proceeded rapidly, but their physiologic relevance to lifestyle modification has been largely ignored. Here we highlight the role of dietary input, specifically carbohydrate intake, in the mechanism of metabolic regulation germane to metabolic syndrome. The key principle is that carbohydrate, directly or indirectly through the effect of insulin, controls the disposition of excess dietary nutrients. Dietary carbohydrate modulates lipolysis, lipoprotein assembly and processing and affects the relation between dietary intake of saturated fat intake and circulating levels. Several of these processes are the subject of intense investigation at the cellular level. We see the need to integrate these cellular mechanisms with results from low-carbohydrate diet trials that have shown reduced cardiovascular risk through improvement in hepatic, intravascular, and peripheral processing of lipoproteins, alterations in fatty acid composition, and reductions in other cardiovascular risk factors, notably inflammation. From the current state of the literature, however, low-carbohydrate diets are grounded in basic metabolic principles and the data suggest that some form of carbohydrate restriction is a candidate to be the preferred dietary strategy for cardiovascular health beyond weight regulation." @default.
- W2028638156 created "2016-06-24" @default.
- W2028638156 creator A5017102102 @default.
- W2028638156 creator A5071325145 @default.
- W2028638156 creator A5080442301 @default.
- W2028638156 creator A5088595086 @default.
- W2028638156 date "2008-09-01" @default.
- W2028638156 modified "2023-10-05" @default.
- W2028638156 title "Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome" @default.
- W2028638156 cites W1669871566 @default.
- W2028638156 cites W1748636648 @default.
- W2028638156 cites W1767446315 @default.
- W2028638156 cites W1785567941 @default.
- W2028638156 cites W1789588774 @default.
- W2028638156 cites W1950560978 @default.
- W2028638156 cites W1954587593 @default.
- W2028638156 cites W1955541934 @default.
- W2028638156 cites W1970226275 @default.
- W2028638156 cites W1970653898 @default.
- W2028638156 cites W1973053270 @default.
- W2028638156 cites W1975459913 @default.
- W2028638156 cites W1979133364 @default.
- W2028638156 cites W1981841268 @default.
- W2028638156 cites W1982040758 @default.
- W2028638156 cites W1982549240 @default.
- W2028638156 cites W1986884589 @default.
- W2028638156 cites W2004120544 @default.
- W2028638156 cites W2004995846 @default.
- W2028638156 cites W2009013500 @default.
- W2028638156 cites W2012577161 @default.
- W2028638156 cites W2012582242 @default.
- W2028638156 cites W2014701219 @default.
- W2028638156 cites W2018168653 @default.
- W2028638156 cites W2025491152 @default.
- W2028638156 cites W2032169646 @default.
- W2028638156 cites W2035657933 @default.
- W2028638156 cites W2036968137 @default.
- W2028638156 cites W2037379679 @default.
- W2028638156 cites W2039928578 @default.
- W2028638156 cites W2041639516 @default.
- W2028638156 cites W2044437167 @default.
- W2028638156 cites W2046366979 @default.
- W2028638156 cites W2054571412 @default.
- W2028638156 cites W2057484292 @default.
- W2028638156 cites W2058075760 @default.
- W2028638156 cites W2059298404 @default.
- W2028638156 cites W2059814953 @default.
- W2028638156 cites W2060026407 @default.
- W2028638156 cites W2065000758 @default.
- W2028638156 cites W2071517530 @default.
- W2028638156 cites W2074889340 @default.
- W2028638156 cites W2076058341 @default.
- W2028638156 cites W2083741341 @default.
- W2028638156 cites W2086608819 @default.
- W2028638156 cites W2093051916 @default.
- W2028638156 cites W2093623924 @default.
- W2028638156 cites W2096171864 @default.
- W2028638156 cites W2096949413 @default.
- W2028638156 cites W2098430971 @default.
- W2028638156 cites W2099213899 @default.
- W2028638156 cites W2099255993 @default.
- W2028638156 cites W2101042964 @default.
- W2028638156 cites W2102767551 @default.
- W2028638156 cites W2102785858 @default.
- W2028638156 cites W2106804949 @default.
- W2028638156 cites W2107290206 @default.
- W2028638156 cites W2108291548 @default.
- W2028638156 cites W2109321065 @default.
- W2028638156 cites W2110740609 @default.
- W2028638156 cites W2110982030 @default.
- W2028638156 cites W2113645942 @default.
- W2028638156 cites W2113752634 @default.
- W2028638156 cites W2114628135 @default.
- W2028638156 cites W2118313140 @default.
- W2028638156 cites W2119331212 @default.
- W2028638156 cites W2119624564 @default.
- W2028638156 cites W2120058838 @default.
- W2028638156 cites W2120385990 @default.
- W2028638156 cites W2120867943 @default.
- W2028638156 cites W2122315007 @default.
- W2028638156 cites W2123148431 @default.
- W2028638156 cites W2124922239 @default.
- W2028638156 cites W2125225208 @default.
- W2028638156 cites W2127819032 @default.
- W2028638156 cites W2128132520 @default.
- W2028638156 cites W2129448795 @default.
- W2028638156 cites W2131622156 @default.
- W2028638156 cites W2131984583 @default.
- W2028638156 cites W2131991255 @default.
- W2028638156 cites W2136775856 @default.
- W2028638156 cites W2141647894 @default.
- W2028638156 cites W2141823673 @default.
- W2028638156 cites W2144473676 @default.
- W2028638156 cites W2145615169 @default.
- W2028638156 cites W2145821365 @default.
- W2028638156 cites W2147821167 @default.
- W2028638156 cites W2147851061 @default.
- W2028638156 cites W2148473068 @default.