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• W2028641235 abstract "To assess the stereochemical requirements for efficient alpha2C-adrenoreceptor activation, the enantiomeric forms of m-nitrobiphenyline [(+/-)-5] were prepared and tested on cells expressing the human alpha2-adrenoreceptor subtypes. The importance of chirality was confirmed, since the enantiomer (R)-(+)-5 was much more efficient than (S)-(-)-5 in producing alpha2C-activation. Surprising reversal of enantioselectivity was observed with respect to structurally similar biphenyline [(+/-)-1] whose (S)-(-)-form proved the preferred alpha2C-configuration." @default.
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• W2028641235 date "2007-07-14" @default.
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• W2028641235 title "α₂-Adrenoreceptors Profile Modulation. 3. (<i>R</i>)-(+)-<i>m</i>-Nitrobiphenyline, a New Efficient and α_2C-Subtype Selective Agonist" @default.
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• W2028641235 doi "https://doi.org/10.1021/jm061487a" @default.
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