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- W2028648973 abstract "Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFRα), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFRα antibody or a soluble extracellular fragment of PDGFRα. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell–cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development." @default.
- W2028648973 created "2016-06-24" @default.
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- W2028648973 date "1996-12-01" @default.
- W2028648973 modified "2023-10-09" @default.
- W2028648973 title "PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina" @default.
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- W2028648973 doi "https://doi.org/10.1016/s0896-6273(00)80244-5" @default.
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