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- W2028654235 abstract "Purpose of review To integrate recent studies showing that abnormal Na+ transport in the central nervous system plays a pivotal role in genetic models of salt-sensitive hypertension. Recent findings Na+ transport-regulating mechanisms classically considered to reflect renal control of the blood pressure, i.e. aldosterone–mineralocorticoid receptors–epithelial sodium channels–Na+/K+-ATPase, have now been demonstrated to be present in the central nervous system contributing to regulation of cerebrospinal fluid [Na+] by the choroid plexus and to neuronal responsiveness to cerebrospinal fluid/brain [Na+]. Dysfunction of either or both can activate central nervous system pathways involving ‘ouabain’ and angiotensin type 1 receptor stimulation. The latter causes sympathetic hyperactivity and adrenal release of marinobufagenin − a digitalis-like inhibitor of the α1 Na+/K+-ATPase isoform – both contributing to hypertension on high salt intake. Conversely, specific central nervous system blockade of mineralocorticoid receptors or epithelial sodium channels prevents the development of hypertension on high salt intake, irrespective of the presence of a ‘salt-sensitive kidney’. Variants in the coding regions of some of the genes involved in Na+ transport have been identified, but sodium sensitivity may be mainly determined by abnormal regulation of expression, pointing to primary abnormalities in regulation of transcription. Summary Looking beyond the kidney is providing new insights into mechanisms contributing to salt-sensitive hypertension, which will help to dissect the genetic factors involved and to discover novel strategies to prevent and treat salt-sensitive hypertension." @default.
- W2028654235 created "2016-06-24" @default.
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- W2028654235 date "2006-07-01" @default.
- W2028654235 modified "2023-10-13" @default.
- W2028654235 title "The central role of the brain in salt-sensitive hypertension" @default.
- W2028654235 cites W1493236633 @default.
- W2028654235 cites W1529137549 @default.
- W2028654235 cites W1529177558 @default.
- W2028654235 cites W1608322029 @default.
- W2028654235 cites W1779079224 @default.
- W2028654235 cites W1804694283 @default.
- W2028654235 cites W1877296209 @default.
- W2028654235 cites W1969194630 @default.
- W2028654235 cites W1971280259 @default.
- W2028654235 cites W1974752914 @default.
- W2028654235 cites W1980992263 @default.
- W2028654235 cites W1988088124 @default.
- W2028654235 cites W1989444402 @default.
- W2028654235 cites W2005360149 @default.
- W2028654235 cites W2007352042 @default.
- W2028654235 cites W2008349061 @default.
- W2028654235 cites W2011518960 @default.
- W2028654235 cites W2013663487 @default.
- W2028654235 cites W2016158080 @default.
- W2028654235 cites W2016260953 @default.
- W2028654235 cites W2031875570 @default.
- W2028654235 cites W2043299702 @default.
- W2028654235 cites W2046924003 @default.
- W2028654235 cites W2047163951 @default.
- W2028654235 cites W2054429624 @default.
- W2028654235 cites W2060439238 @default.
- W2028654235 cites W2061360182 @default.
- W2028654235 cites W2062380679 @default.
- W2028654235 cites W2063171346 @default.
- W2028654235 cites W2070649421 @default.
- W2028654235 cites W2071149944 @default.
- W2028654235 cites W2072204588 @default.
- W2028654235 cites W2083467450 @default.
- W2028654235 cites W2084513455 @default.
- W2028654235 cites W2092852891 @default.
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- W2028654235 cites W2116153685 @default.
- W2028654235 cites W2127120893 @default.
- W2028654235 cites W2127979523 @default.
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- W2028654235 doi "https://doi.org/10.1097/01.hco.0000231398.64362.94" @default.
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