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- W2028659128 abstract "The kidney is a major target organ in generalized candidiasis. When mice were infected with C.albicans, prostaglandin E2 (PGE2)-like activity was found to be significantly decreased while leukotriene C4 (LTC4)-like activity increased in the kidneys within 10 days. The aim of this study is to investigate the effect of nordihydroguaretic (NDGA) and fluconazole on the LTC4/PGE2 ratio in the mice kidneys infected by proteinase (+) C. albicans. The LTC4/PGE2 ratio was found to be significantly decreased both in NDGA and fluconazole-pretreated groups. These results indicate that pretreatment with the lipoxygenase inhibitor NDGA and the antifungal drug fluconazole, protect the kidney against C. albicans infection. These results also indicate a possible role of arachidonic acid metabolites (increase LTC4 and decrease PGE2) in kidney damage due to C. albicans infection." @default.
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- W2028659128 date "1997-04-01" @default.
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- W2028659128 title "Effect of nordihydroguaretic acid and fluconazole on the ratio in the kidney of mice damaged by Candida albicans" @default.
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- W2028659128 doi "https://doi.org/10.1016/s0952-3278(97)90571-8" @default.
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