Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028667039> ?p ?o ?g. }
- W2028667039 endingPage "157" @default.
- W2028667039 startingPage "146" @default.
- W2028667039 abstract "Endothelial cells (ECs) form cell-cell adhesive junctional structures maintaining vascular integrity. This barrier is dynamically regulated by vascular endothelial growth factor (VEGF) receptor signaling. We created an inducible knockin mouse model to study the contribution of the integrin-associated focal adhesion tyrosine kinase (FAK) signaling on vascular function. Here we show that genetic or pharmacological FAK inhibition in ECs prevents VEGF-stimulated permeability downstream of VEGF receptor or Src tyrosine kinase activation in vivo. VEGF promotes tension-independent FAK activation, rapid FAK localization to cell-cell junctions, binding of the FAK FERM domain to the vascular endothelial cadherin (VE-cadherin) cytoplasmic tail, and direct FAK phosphorylation of β-catenin at tyrosine-142 (Y142) facilitating VE-cadherin-β-catenin dissociation and EC junctional breakdown. Kinase inhibited FAK is in a closed conformation that prevents VE-cadherin association and limits VEGF-stimulated β-catenin Y142 phosphorylation. Our studies establish a role for FAK as an essential signaling switch within ECs regulating adherens junction dynamics." @default.
- W2028667039 created "2016-06-24" @default.
- W2028667039 creator A5006498849 @default.
- W2028667039 creator A5007664626 @default.
- W2028667039 creator A5027036542 @default.
- W2028667039 creator A5030557212 @default.
- W2028667039 creator A5030957947 @default.
- W2028667039 creator A5039178057 @default.
- W2028667039 creator A5041901585 @default.
- W2028667039 creator A5047509310 @default.
- W2028667039 creator A5049731648 @default.
- W2028667039 creator A5054495808 @default.
- W2028667039 creator A5059200730 @default.
- W2028667039 creator A5064957549 @default.
- W2028667039 creator A5081651835 @default.
- W2028667039 creator A5089796560 @default.
- W2028667039 creator A5090973852 @default.
- W2028667039 date "2012-01-01" @default.
- W2028667039 modified "2023-10-13" @default.
- W2028667039 title "VEGF-Induced Vascular Permeability Is Mediated by FAK" @default.
- W2028667039 cites W1482725342 @default.
- W2028667039 cites W1904209158 @default.
- W2028667039 cites W1964020745 @default.
- W2028667039 cites W1967150229 @default.
- W2028667039 cites W1975216289 @default.
- W2028667039 cites W1993255535 @default.
- W2028667039 cites W1996537616 @default.
- W2028667039 cites W2000292756 @default.
- W2028667039 cites W2005817040 @default.
- W2028667039 cites W2010045296 @default.
- W2028667039 cites W2016576487 @default.
- W2028667039 cites W2018512891 @default.
- W2028667039 cites W2025559292 @default.
- W2028667039 cites W2029315212 @default.
- W2028667039 cites W2037195684 @default.
- W2028667039 cites W2040593473 @default.
- W2028667039 cites W2044895919 @default.
- W2028667039 cites W2047392037 @default.
- W2028667039 cites W2053144070 @default.
- W2028667039 cites W2057711788 @default.
- W2028667039 cites W2058843732 @default.
- W2028667039 cites W2059407064 @default.
- W2028667039 cites W2059476028 @default.
- W2028667039 cites W2065088072 @default.
- W2028667039 cites W2071601082 @default.
- W2028667039 cites W2073576611 @default.
- W2028667039 cites W2074070818 @default.
- W2028667039 cites W2074828584 @default.
- W2028667039 cites W2083775288 @default.
- W2028667039 cites W2085538915 @default.
- W2028667039 cites W2099685361 @default.
- W2028667039 cites W2100484841 @default.
- W2028667039 cites W2102600746 @default.
- W2028667039 cites W2105766219 @default.
- W2028667039 cites W2114462664 @default.
- W2028667039 cites W2114876832 @default.
- W2028667039 cites W2119690971 @default.
- W2028667039 cites W2128378329 @default.
- W2028667039 cites W2137417447 @default.
- W2028667039 cites W2142682878 @default.
- W2028667039 cites W2145392559 @default.
- W2028667039 cites W2151914619 @default.
- W2028667039 cites W2152869165 @default.
- W2028667039 cites W2152996519 @default.
- W2028667039 cites W2156130533 @default.
- W2028667039 cites W2160826303 @default.
- W2028667039 cites W4241779034 @default.
- W2028667039 cites W4254123044 @default.
- W2028667039 doi "https://doi.org/10.1016/j.devcel.2011.11.002" @default.
- W2028667039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266538" @default.
- W2028667039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22264731" @default.
- W2028667039 hasPublicationYear "2012" @default.
- W2028667039 type Work @default.
- W2028667039 sameAs 2028667039 @default.
- W2028667039 citedByCount "283" @default.
- W2028667039 countsByYear W20286670392012 @default.
- W2028667039 countsByYear W20286670392013 @default.
- W2028667039 countsByYear W20286670392014 @default.
- W2028667039 countsByYear W20286670392015 @default.
- W2028667039 countsByYear W20286670392016 @default.
- W2028667039 countsByYear W20286670392017 @default.
- W2028667039 countsByYear W20286670392018 @default.
- W2028667039 countsByYear W20286670392019 @default.
- W2028667039 countsByYear W20286670392020 @default.
- W2028667039 countsByYear W20286670392021 @default.
- W2028667039 countsByYear W20286670392022 @default.
- W2028667039 countsByYear W20286670392023 @default.
- W2028667039 crossrefType "journal-article" @default.
- W2028667039 hasAuthorship W2028667039A5006498849 @default.
- W2028667039 hasAuthorship W2028667039A5007664626 @default.
- W2028667039 hasAuthorship W2028667039A5027036542 @default.
- W2028667039 hasAuthorship W2028667039A5030557212 @default.
- W2028667039 hasAuthorship W2028667039A5030957947 @default.
- W2028667039 hasAuthorship W2028667039A5039178057 @default.
- W2028667039 hasAuthorship W2028667039A5041901585 @default.
- W2028667039 hasAuthorship W2028667039A5047509310 @default.
- W2028667039 hasAuthorship W2028667039A5049731648 @default.
- W2028667039 hasAuthorship W2028667039A5054495808 @default.