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• W2028667086 startingPage "498" @default.
• W2028667086 abstract "Hepatocellular carcinoma (HCC) is a lethal disease in most patients, due to its aggressive course and a lack of effective systemic therapies for advanced disease. Surgical resection and liver transplantation remain the only curative options for a small subset of patients. Few patients with HCC are diagnosed early enough to be eligible for curative treatment. Angiogenesis inhibition is a natural therapeutic target for all solid tumors, but particularly for the highly vascularized HCC tumors. With the approval of the targeted agent sorafenib, there are now additional options for patients with HCC. Although sorafenib does produce some improvement in survival in HCC patients, the responses are not durable. In addition, there are significant dermatologic, gastrointestinal, and metabolic toxicities, and, as importantly, there is still limited knowledge of its usefulness in special subpopulations with HCC. Other angiogenesis inhibitors are in development to treat HCC both in the first-line setting and for use following sorafenib failure; the furthest in development is brivanib, a dual fibroblast growth factor pathway and vascular endothelial growth factor receptor inhibitor. Additional agents with antiangiogenic properties also in phase II and III development for the treatment of patients with HCC include bevacizumab, ramucirumab, ABT-869, everolimus and ARQ 197." @default.
• W2028667086 created "2016-06-24" @default.
• W2028667086 creator A5009446007 @default.
• W2028667086 creator A5039204539 @default.
• W2028667086 date "2012-01-01" @default.
• W2028667086 modified "2023-09-28" @default.
• W2028667086 title "Targeted systemic therapies for hepatocellular carcinoma: Clinical perspectives, challenges and implications" @default.
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• W2028667086 doi "https://doi.org/10.3748/wjg.v18.i6.498" @default.
• W2028667086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280394" @default.
• W2028667086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22363115" @default.
• W2028667086 hasPublicationYear "2012" @default.
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