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- W2028669103 abstract "Three novel analogues of antiarrhythmic peptide (AAP), [Sar 2 , Pro 3 ]AAP ( I ), [Sar 3 ]AAP ( II ) and [Sar 2 , Sar 3 ]AAP ( III ), have been synthesized in order to get peptides with enhanced antiarrhythmic activity. Their antiarrhythmic activity has been evaluated against aconitine induced arrhythmia in rats. [Sar 2 , Sar 3 ]AAP has been found to be more active than AAP. It is equipotent to the commonly used antiarrhythmic drug quinidine, so far as delay in the onset of ventricular tachycardia, ventricular fibrillation and cardiac arrest are concerned. Relationship of biological activities of these peptides with their CD is discussed. The results suggest that the spatial structure of III attributed to Sar 2 -Sar 3 linkage might be contributing to its higher antiarrhythmic activity." @default.
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- W2028669103 date "1990-01-01" @default.
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- W2028669103 title "Antiarrhythmic activity of a novel analogue of AAP" @default.
- W2028669103 doi "https://doi.org/10.1135/cccc19900575" @default.
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