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- W2028678429 abstract "A high-performance liquid chromatographic method is described for the determination of paroxetine in human plasma. Dibucaine was used as the internal standard. Paroxetine was isolated by solid phase extraction using a Bond-Elut C18 extraction column. Separation was obtained using a reversed-phase column under isocratic conditions with fluorescence detection. The sample volume was 500 μl of plasma. The intra- and inter-assay accuracy and precision, determined as relative error and relative standard deviation, respectively, were less than 10%. The lower limit of quantitation, based on standards with acceptable relative error and relative standard deviation, was 10 ng ml−1. No endogenous compounds were found to interfere. The linearity was assessed in the range 5–100 ng ml−1. Stability of paroxetine during processing (autosampler) and in plasma was checked. This method proved suitable for bioequivalence studies following multiple doses in healthy volunteers." @default.
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- W2028678429 title "Determination of paroxetine in plasma by high-performance liquid chromatography for bioequivalence studies" @default.
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- W2028678429 doi "https://doi.org/10.1016/s0378-4347(98)00560-x" @default.
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