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- W2028687560 abstract "A method is described for measurement of plasma methadone concentrations using a gas chromatic technique that is rapid and specific and enables the detection of concentrations of less than 1 ng/ml in plasma samples of only 1 ml. The method, when used to determine the plasma methadone levels in patients given continuous epidural infusions of methadone plus on-demand supplementation for relief of postoperative pain, showed plasma methadone plateaus of around 10 ng/ml (starting at 15 min and lasting over 2 hr) and 20 ng/ml (starting at 3 hr and lasting over the period of treatment) (P less than 0.001) after an initial 2-mg methadone epidural bolus and with continuous epidural methadone. Mean plasma methadone levels of around 10 ng/ml were associated with pain relief. Analgesia could be safely maintained for 24 hr." @default.
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- W2028687560 date "1987-12-01" @default.
- W2028687560 modified "2023-09-26" @default.
- W2028687560 title "Application of a New Method for Measurement of Plasma Methadone Levels to the Use of Epidural Methadone for Relief of Postoperative Pain" @default.
- W2028687560 doi "https://doi.org/10.1213/00000539-198712000-00019" @default.
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