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- W2028697308 abstract "The effects of changes of membrane potential on amino acid transport through systems A, ASC and L was investigated in the Ehrlich cell and the human erythrocyte. Changes of membrane potential were produced by incubating cells whose K+ permeability had been increased, either by valinomycin or by activation of Ca2+-dependent K+ channels, in medium containing different K+ concentrations. The changes in membrane potential were followed by measuring the distribution ratio reached by lipophilic indicators. Transport through Na+-dependent system A was sensitive to the membrane potential, the rate of amino acid uptake increasing 2.2-3.1-times for each 60 mV-hyperpolarization. The Na+-dependent system ASC was insensitive to membrane potential. The Na+-independent system L was not directly affected by membrane potential, but the steady-state accumulation of system L substrates was increased by hyperpolarization." @default.
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- W2028697308 date "1986-06-01" @default.
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- W2028697308 title "Differential effects of transmembrane potential on two Na+-dependent transport systems for neutral amino acids" @default.
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- W2028697308 doi "https://doi.org/10.1016/0005-2736(86)90304-4" @default.
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