FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028698149> ?p ?o ?g. }

• W2028698149 endingPage "9" @default.
• W2028698149 startingPage "1" @default.
• W2028698149 abstract "We used flow cytometry to analyze the cell cycle, DNA damage, and apoptosis in hematopoietic subsets in MDS marrow. Subsets were assigned using CD45, side scatter, CD34, and CD71. Cell cycle fractions were analyzed using DRAQ 5 (DNA content) and MPM-2 (mitoses). DNA damage was assessed using p-H2A.X, and apoptosis using Annexin V. Compared to controls, MDS patients demonstrated no increased mitoses in erythroid, myeloid, or CD34+ cells. Myeloid progenitors demonstrated increased G2 cells, which with no increased mitoses suggested delayed passage through G2. Myeloid progenitors demonstrated increased p-H2A.X, consistent with DNA damage causing this delay. Annexin V reactivity was equivalent in MDS and controls. Results for each parameter varied among hematopoietic compartments, demonstrating the need to analyze compartments separately. Our results suggest that peripheral cytopenias in MDS are due to delayed cell cycle passage of marrow progenitors and that this delayed passage and leukemic progression derive from excessive DNA damage." @default.
• W2028698149 created "2016-06-24" @default.
• W2028698149 creator A5005996885 @default.
• W2028698149 creator A5006983912 @default.
• W2028698149 creator A5007675643 @default.
• W2028698149 creator A5008769267 @default.
• W2028698149 creator A5022835776 @default.
• W2028698149 creator A5027059513 @default.
• W2028698149 creator A5037312131 @default.
• W2028698149 creator A5040683449 @default.
• W2028698149 creator A5053618229 @default.
• W2028698149 creator A5066341647 @default.
• W2028698149 creator A5070008988 @default.
• W2028698149 creator A5074107549 @default.
• W2028698149 date "2011-06-07" @default.
• W2028698149 modified "2023-10-16" @default.
• W2028698149 title "Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis" @default.
• W2028698149 cites W187238933 @default.
• W2028698149 cites W1967383504 @default.
• W2028698149 cites W1977897164 @default.
• W2028698149 cites W1983781920 @default.
• W2028698149 cites W1985775217 @default.
• W2028698149 cites W1999904677 @default.
• W2028698149 cites W2001979268 @default.
• W2028698149 cites W2002062621 @default.
• W2028698149 cites W2004421590 @default.
• W2028698149 cites W2028029183 @default.
• W2028698149 cites W2028296653 @default.
• W2028698149 cites W2059336414 @default.
• W2028698149 cites W2061549613 @default.
• W2028698149 cites W2074346914 @default.
• W2028698149 cites W2081407910 @default.
• W2028698149 cites W2096573123 @default.
• W2028698149 cites W2096880268 @default.
• W2028698149 cites W2097198718 @default.
• W2028698149 cites W2102657434 @default.
• W2028698149 cites W2106845421 @default.
• W2028698149 cites W2114487246 @default.
• W2028698149 cites W2156794452 @default.
• W2028698149 doi "https://doi.org/10.1155/2011/950934" @default.
• W2028698149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3200066" @default.
• W2028698149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22046573" @default.
• W2028698149 hasPublicationYear "2011" @default.
• W2028698149 type Work @default.
• W2028698149 sameAs 2028698149 @default.
• W2028698149 citedByCount "6" @default.
• W2028698149 countsByYear W20286981492012 @default.
• W2028698149 countsByYear W20286981492013 @default.
• W2028698149 countsByYear W20286981492014 @default.
• W2028698149 countsByYear W20286981492015 @default.
• W2028698149 countsByYear W20286981492016 @default.
• W2028698149 countsByYear W20286981492021 @default.
• W2028698149 crossrefType "journal-article" @default.
• W2028698149 hasAuthorship W2028698149A5005996885 @default.
• W2028698149 hasAuthorship W2028698149A5006983912 @default.
• W2028698149 hasAuthorship W2028698149A5007675643 @default.
• W2028698149 hasAuthorship W2028698149A5008769267 @default.
• W2028698149 hasAuthorship W2028698149A5022835776 @default.
• W2028698149 hasAuthorship W2028698149A5027059513 @default.
• W2028698149 hasAuthorship W2028698149A5037312131 @default.
• W2028698149 hasAuthorship W2028698149A5040683449 @default.
• W2028698149 hasAuthorship W2028698149A5053618229 @default.
• W2028698149 hasAuthorship W2028698149A5066341647 @default.
• W2028698149 hasAuthorship W2028698149A5070008988 @default.
• W2028698149 hasAuthorship W2028698149A5074107549 @default.
• W2028698149 hasBestOaLocation W20286981491 @default.
• W2028698149 hasConcept C10205521 @default.
• W2028698149 hasConcept C109159458 @default.
• W2028698149 hasConcept C143425029 @default.
• W2028698149 hasConcept C190283241 @default.
• W2028698149 hasConcept C201750760 @default.
• W2028698149 hasConcept C203014093 @default.
• W2028698149 hasConcept C2778729363 @default.
• W2028698149 hasConcept C2779282312 @default.
• W2028698149 hasConcept C2780007613 @default.
• W2028698149 hasConcept C2780817109 @default.
• W2028698149 hasConcept C28328180 @default.
• W2028698149 hasConcept C29537977 @default.
• W2028698149 hasConcept C502942594 @default.
• W2028698149 hasConcept C54355233 @default.
• W2028698149 hasConcept C552990157 @default.
• W2028698149 hasConcept C553184892 @default.
• W2028698149 hasConcept C71924100 @default.
• W2028698149 hasConcept C86803240 @default.
• W2028698149 hasConcept C93304396 @default.
• W2028698149 hasConcept C95444343 @default.
• W2028698149 hasConceptScore W2028698149C10205521 @default.
• W2028698149 hasConceptScore W2028698149C109159458 @default.
• W2028698149 hasConceptScore W2028698149C143425029 @default.
• W2028698149 hasConceptScore W2028698149C190283241 @default.
• W2028698149 hasConceptScore W2028698149C201750760 @default.
• W2028698149 hasConceptScore W2028698149C203014093 @default.
• W2028698149 hasConceptScore W2028698149C2778729363 @default.
• W2028698149 hasConceptScore W2028698149C2779282312 @default.
• W2028698149 hasConceptScore W2028698149C2780007613 @default.
• W2028698149 hasConceptScore W2028698149C2780817109 @default.
• W2028698149 hasConceptScore W2028698149C28328180 @default.
• W2028698149 hasConceptScore W2028698149C29537977 @default.

• next