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- W2028698596 abstract "This study examines the effects of two converting enzyme inhibitors (captopril and enalaprilat) and two α-adrenergic receptor antagonists (phentolamine and phenoxybenzamine) on the pressor response produced by exogenous angiotensin I ([Asp1, Val5, Ser9] ANG I, fowl) and [Val5] angiotensin II (ANG II) in the American alligator (Alligator mississippiensis). Bolus administration of ANG I at 0.1, 0.5, and 1.0 μg/kg; ANG II at 0.05, 0.1, and 0.5 μg/kg; or norepinephrine (NE) at 2 μg/kg elicited dose-dependent increases in arterial blood pressure. Captopril (0.5 mg/kg/hr) and enalaprilat (300 μg/kg/hr) significantly reduced the response to ANG I, but not ANG II or NE. Both phenoxybenzamine (0.25 mg/kg/min) and phentolamine (1 mg/kg/hr) effectively blocked the NE pressor response (84 and 88%, respectively) and attenuated (42–80%) the pressor effects of ANG I and ANG II. These results support previous work suggesting the alligator may possess a renin-angiotensin system with characteristics similar to those found in mammals and other vertebrates. In addition, the pressor response to exogenously administered ANG I and ANG II was attenuated by α adrenergic receptor blockade and thus may be due, in part, to secondary catecholamine release." @default.
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- W2028698596 date "1992-07-01" @default.
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- W2028698596 title "Effects of converting enzyme inhibition and α receptor blockade on the angiotensin pressor response in the American alligator" @default.
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- W2028698596 doi "https://doi.org/10.1016/0016-6480(92)90159-h" @default.
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