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• W2028703398 endingPage "550" @default.
• W2028703398 startingPage "531" @default.
• W2028703398 abstract "In higher eukaryotes, most secretory and membrane proteins are synthesised by ribosomes which are attached to the membrane of the rough endoplasmic reticulum (RER). This allows the proteins to be translocated across that membrane already during their synthesis. The ribosomes are directed to the RER membrane by a cytoplasmic ribonucleoprotein particle, the signal recognition particle (SRP). SRP fulfills its task by virtue of three distinguishable activities: the binding of a signal sequence which, being part of the nascent polypeptide to be translocated, is exposed on the surface of a translating ribosome; the retardation of any further elongation; and the SRP-receptor-mediated binding of the complex of ribosome, nascent polypeptide and SRP to the RER membrane which results in the detachment of SRP from the signal sequence and the ribosome and the insertion of the nascent polypeptide into the membrane. Evidence is accumulating that SRP is not restricted to eukaryotes: SRP-related particles and SRP-receptor-related molecules are found ubiquitously and may function in protein translocation in every living organism. This review focuses on the mammalian SRP. A brief discussion of its overall structure is followed by a detailed description of the structures of its RNA and protein constituents and the requirements for their assembly into the particle. Homologues of SRP components from organisms other than mammals are mentioned to emphasize the components' conserved or less conserved features. Subsequently, the functions of each of the SRP constituents are discussed. This sets the stage for a presentation of a model for the mechanism by which SRP cyclically assembles and disassembles with translating ribosomes and the RER membrane. It may be expected that similar mechanisms are used by SRP homologues in organisms other than mammals. However, the mammalian SRP-mediated translocation mechanism may not be conserved in its entirety in organisms like Escherichia coli whose SRP lack components required for the function of the mammalian SRP. Possible translocation pathways involving the rudimentary SRP are discussed in view of the existence of alternative, chaperone-mediated translocation pathways with which they may intersect. The concluding two sections deal with open questions in two areas of SRP research. One formulates basic questions regarding the little-investigated biogenesis of SRP. The other gives an outlook over the insights into the mechanisms of each of the known activities of the SRP that are to be expected in the short and medium-term future." @default.
• W2028703398 created "2016-06-24" @default.
• W2028703398 creator A5024030140 @default.
• W2028703398 date "1995-03-01" @default.
• W2028703398 modified "2023-10-18" @default.
• W2028703398 title "Signal Recognition Particle (SRP), a Ubiquitous Initiator of Protein Translocation" @default.
• W2028703398 cites W101572434 @default.
• W2028703398 cites W113936184 @default.
• W2028703398 cites W117684456 @default.
• W2028703398 cites W124157494 @default.
• W2028703398 cites W1272547789 @default.
• W2028703398 cites W1410230233 @default.
• W2028703398 cites W149933225 @default.
• W2028703398 cites W1552874512 @default.
• W2028703398 cites W156102329 @default.
• W2028703398 cites W1627679017 @default.
• W2028703398 cites W176289290 @default.
• W2028703398 cites W1799375255 @default.
• W2028703398 cites W1810394673 @default.
• W2028703398 cites W181760639 @default.
• W2028703398 cites W1826353084 @default.
• W2028703398 cites W1831909171 @default.
• W2028703398 cites W1847631906 @default.
• W2028703398 cites W1848544460 @default.
• W2028703398 cites W1856186269 @default.
• W2028703398 cites W1860416701 @default.
• W2028703398 cites W1878346008 @default.
• W2028703398 cites W1884121632 @default.
• W2028703398 cites W1916946291 @default.
• W2028703398 cites W1938929720 @default.
• W2028703398 cites W1965731203 @default.
• W2028703398 cites W1966229630 @default.
• W2028703398 cites W1968901680 @default.
• W2028703398 cites W1971447046 @default.
• W2028703398 cites W1973706463 @default.
• W2028703398 cites W1973792741 @default.
• W2028703398 cites W1976534033 @default.
• W2028703398 cites W1976880811 @default.
• W2028703398 cites W1977388184 @default.
• W2028703398 cites W1977495264 @default.
• W2028703398 cites W1977598234 @default.
• W2028703398 cites W1978752252 @default.
• W2028703398 cites W1979027806 @default.
• W2028703398 cites W1980355157 @default.
• W2028703398 cites W1981589859 @default.
• W2028703398 cites W1981610784 @default.
• W2028703398 cites W1981790879 @default.
• W2028703398 cites W1983931221 @default.
• W2028703398 cites W1988184748 @default.
• W2028703398 cites W1989145007 @default.
• W2028703398 cites W1989789175 @default.
• W2028703398 cites W1991467177 @default.
• W2028703398 cites W1992470956 @default.
• W2028703398 cites W1996592126 @default.
• W2028703398 cites W1996899427 @default.
• W2028703398 cites W1997487250 @default.
• W2028703398 cites W1999838506 @default.
• W2028703398 cites W2001977025 @default.
• W2028703398 cites W2003178039 @default.
• W2028703398 cites W2005189737 @default.
• W2028703398 cites W2005383788 @default.
• W2028703398 cites W2007175873 @default.
• W2028703398 cites W2013674606 @default.
• W2028703398 cites W2014601071 @default.
• W2028703398 cites W2018377801 @default.
• W2028703398 cites W2019960434 @default.
• W2028703398 cites W2020558560 @default.
• W2028703398 cites W2024385459 @default.
• W2028703398 cites W2031928793 @default.
• W2028703398 cites W2031933687 @default.
• W2028703398 cites W2032401696 @default.
• W2028703398 cites W2033837701 @default.
• W2028703398 cites W2035621280 @default.
• W2028703398 cites W2035696460 @default.
• W2028703398 cites W2036766833 @default.
• W2028703398 cites W2037815140 @default.
• W2028703398 cites W2038272471 @default.
• W2028703398 cites W2038605297 @default.
• W2028703398 cites W2039140102 @default.
• W2028703398 cites W2040232267 @default.
• W2028703398 cites W2046240394 @default.
• W2028703398 cites W2046913913 @default.
• W2028703398 cites W2047766633 @default.
• W2028703398 cites W2050774163 @default.
• W2028703398 cites W2051250838 @default.
• W2028703398 cites W2051293392 @default.
• W2028703398 cites W2052586760 @default.
• W2028703398 cites W2054707540 @default.
• W2028703398 cites W2058273091 @default.
• W2028703398 cites W2061420370 @default.
• W2028703398 cites W2061492608 @default.
• W2028703398 cites W2064607219 @default.
• W2028703398 cites W2064818644 @default.
• W2028703398 cites W2064933691 @default.
• W2028703398 cites W2066116873 @default.
• W2028703398 cites W2066906496 @default.
• W2028703398 cites W2068616417 @default.
• W2028703398 cites W2070336844 @default.

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