Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028713040> ?p ?o ?g. }
- W2028713040 endingPage "439" @default.
- W2028713040 startingPage "435" @default.
- W2028713040 abstract "Purpose of review Nocebo hyperalgesia is a phenomenon that is opposite to placebo analgesia and whereby expectation of pain increase plays a crucial role. In recent times, both the neuroanatomical and the neurochemical bases of the nocebo effect and of nocebo-related effects have begun to be explored. Here, we highlight recent advances in our understanding of the neurobiology of the nocebo hyperalgesic effect. Recent findings A typical nocebo hyperalgesic response occurs following the administration of an inert substance which the subject believes to be a hyperalgesic agent (negative placebo or nocebo). It has been shown that the subject's negative expectations of pain worsening induce anticipatory anxiety about the impending pain increase and this triggers the activation of cholecystokinin that, in turn, facilitates pain transmission. Accordingly, cholecystokinin antagonists have been found to prevent this anxiety-induced hyperalgesia. Brain-imaging studies have shown that the perceived intensity of a painful stimulus following negative expectations of pain increase is higher than in the absence of negative expectations and this is associated with changes in activation of specific brain regions. Summary Since pain appears to be amplified by anxiety through the activation of cholecystokininergic systems, new therapeutic strategies, such as new cholecystokinin antagonists, can be envisaged whenever pain has an important anxiety component." @default.
- W2028713040 created "2016-06-24" @default.
- W2028713040 creator A5013363780 @default.
- W2028713040 creator A5017306126 @default.
- W2028713040 date "2007-10-01" @default.
- W2028713040 modified "2023-10-02" @default.
- W2028713040 title "Nocebo hyperalgesia: how anxiety is turned into pain" @default.
- W2028713040 cites W1654586824 @default.
- W2028713040 cites W1775562370 @default.
- W2028713040 cites W1879930895 @default.
- W2028713040 cites W1897575770 @default.
- W2028713040 cites W1989360695 @default.
- W2028713040 cites W2005425813 @default.
- W2028713040 cites W2007739911 @default.
- W2028713040 cites W2011285008 @default.
- W2028713040 cites W2013564506 @default.
- W2028713040 cites W2019030815 @default.
- W2028713040 cites W2021962154 @default.
- W2028713040 cites W2025845157 @default.
- W2028713040 cites W2026747063 @default.
- W2028713040 cites W2030711540 @default.
- W2028713040 cites W2032466194 @default.
- W2028713040 cites W2043074725 @default.
- W2028713040 cites W2046251010 @default.
- W2028713040 cites W2050896447 @default.
- W2028713040 cites W2052485536 @default.
- W2028713040 cites W2058725879 @default.
- W2028713040 cites W2060426624 @default.
- W2028713040 cites W2061372369 @default.
- W2028713040 cites W2067268774 @default.
- W2028713040 cites W2067552820 @default.
- W2028713040 cites W2070268037 @default.
- W2028713040 cites W2073541554 @default.
- W2028713040 cites W2075075486 @default.
- W2028713040 cites W2079680152 @default.
- W2028713040 cites W2094347820 @default.
- W2028713040 cites W2094738599 @default.
- W2028713040 cites W2099093791 @default.
- W2028713040 cites W2103393785 @default.
- W2028713040 cites W2104135024 @default.
- W2028713040 cites W2125295858 @default.
- W2028713040 cites W2127113745 @default.
- W2028713040 cites W2130690736 @default.
- W2028713040 cites W2133687031 @default.
- W2028713040 cites W2135382170 @default.
- W2028713040 cites W2135951181 @default.
- W2028713040 cites W2148993214 @default.
- W2028713040 cites W2149515128 @default.
- W2028713040 cites W2152161376 @default.
- W2028713040 cites W2160308384 @default.
- W2028713040 cites W2160938249 @default.
- W2028713040 cites W2415075414 @default.
- W2028713040 cites W4249624926 @default.
- W2028713040 cites W4313371689 @default.
- W2028713040 doi "https://doi.org/10.1097/aco.0b013e3282b972fb" @default.
- W2028713040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17873596" @default.
- W2028713040 hasPublicationYear "2007" @default.
- W2028713040 type Work @default.
- W2028713040 sameAs 2028713040 @default.
- W2028713040 citedByCount "289" @default.
- W2028713040 countsByYear W20287130402012 @default.
- W2028713040 countsByYear W20287130402013 @default.
- W2028713040 countsByYear W20287130402014 @default.
- W2028713040 countsByYear W20287130402015 @default.
- W2028713040 countsByYear W20287130402016 @default.
- W2028713040 countsByYear W20287130402017 @default.
- W2028713040 countsByYear W20287130402018 @default.
- W2028713040 countsByYear W20287130402019 @default.
- W2028713040 countsByYear W20287130402020 @default.
- W2028713040 countsByYear W20287130402021 @default.
- W2028713040 countsByYear W20287130402022 @default.
- W2028713040 countsByYear W20287130402023 @default.
- W2028713040 crossrefType "journal-article" @default.
- W2028713040 hasAuthorship W2028713040A5013363780 @default.
- W2028713040 hasAuthorship W2028713040A5017306126 @default.
- W2028713040 hasConcept C118552586 @default.
- W2028713040 hasConcept C126322002 @default.
- W2028713040 hasConcept C142724271 @default.
- W2028713040 hasConcept C15490471 @default.
- W2028713040 hasConcept C15744967 @default.
- W2028713040 hasConcept C169760540 @default.
- W2028713040 hasConcept C170493617 @default.
- W2028713040 hasConcept C204787440 @default.
- W2028713040 hasConcept C25876315 @default.
- W2028713040 hasConcept C27081682 @default.
- W2028713040 hasConcept C2777593968 @default.
- W2028713040 hasConcept C2778360308 @default.
- W2028713040 hasConcept C2779245659 @default.
- W2028713040 hasConcept C2780444219 @default.
- W2028713040 hasConcept C2909182145 @default.
- W2028713040 hasConcept C42219234 @default.
- W2028713040 hasConcept C558461103 @default.
- W2028713040 hasConcept C70410870 @default.
- W2028713040 hasConcept C71924100 @default.
- W2028713040 hasConceptScore W2028713040C118552586 @default.
- W2028713040 hasConceptScore W2028713040C126322002 @default.
- W2028713040 hasConceptScore W2028713040C142724271 @default.
- W2028713040 hasConceptScore W2028713040C15490471 @default.