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• W2028715058 abstract "HomeHypertensionVol. 12, No. 3Cardiogenic hypertension in maturing dogs. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBCardiogenic hypertension in maturing dogs. F Magrini, N Roberts, G Branzi, C Mondadori, P Reggiani, M Ciulla and R Meazza F MagriniF Magrini Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author , N RobertsN Roberts Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author , G BranziG Branzi Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author , C MondadoriC Mondadori Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author , P ReggianiP Reggiani Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author , M CiullaM Ciulla Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author and R MeazzaR Meazza Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. Search for more papers by this author Originally published1 Sep 1988https://doi.org/10.1161/01.HYP.12.3.295Hypertension. 1988;12:295–300AbstractThe purpose of this study was to evaluate whether the heart can induce high blood pressure by maintaining an inappropriately elevated cardiac output/body weight ratio during growth. Direct (femoral artery) mean arterial pressure (MAP), heart rate, cardiac output/body weight ratio (as defined by M-mode echocardiography), and total peripheral vascular resistance were measured and calculated every 2 months in nine conscious dogs during development from 2 to 10 months of age. In four dogs a J-shaped catheter for atrial pacing was chronically implanted at the age of 3 months, and their hearts were permanently paced at 130 beats/min until maturity. The aim of atrial pacing was to prevent the natural slowing of the heart rate and, consequently, to maintain a cardiac output/body weight ratio that was inappropriately high in relation to age during growth. Five dogs were studied as controls. No hemodynamic differences were observed until the age of 4 months. From the age of 5 to 10 months heart rate was kept at 130 beats/min by atrial pacing in the atrially paced group, and the mean cardiac output/body weight ratio did not decrease (196 +/- 24 vs 191 +/- 34 [SE] ml/min/kg). MAP rose from 62 +/- 4 to 116 +/- 8 mm Hg, and total peripheral resistance increased from 0.34 +/- 0.07 to to 0.61 +/- 0.09 mm Hg/ml/min/kg.(ABSTRACT TRUNCATED AT 250 WORDS) Previous Back to top Next FiguresReferencesRelatedDetails September 1988Vol 12, Issue 3 Advertisement Article InformationMetrics Copyright © 1988 by American Heart Associationhttps://doi.org/10.1161/01.HYP.12.3.295PMID: 3169944 Originally publishedSeptember 1, 1988 PDF download Advertisement" @default.
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• W2028715058 title "Cardiogenic hypertension in maturing dogs." @default.
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