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• W2028734519 abstract "1 We studied the release of [3H]-dopamine and [3H]-noradrenaline (NA) from hippocampal synap-tosomes induced by glutamate receptors and the associated Ca2+ influx through Ca2+ channels. The release of tritiated neurotransmitters was studied by use of superfusion system and the intracellular free Ca2+ concentration ([Ca2+]i) was determined by a fluorimetric assay with Indo-1 as a probe for Ca2+. 2 Presynaptic glutamate receptor activation induced Ca2+-dependent release of [3H]-dopamine and [3H]-NA from rat hippocampal synaptosomes. Thus, L-glutamate induced the release of both neurotransmitters in a dose-dependent manner (EC50 = 5.62 μm), and the effect of 100 μm L-glutamate was inhibited by 83.8% in the presence of 10 μm 6-cyano-7-nitroquinoxaline-2,3-dioxine (CNQX), but was not affected by 1 μm (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine (MK-801). 3 Other glutamate receptor agonists also stimulated the Ca2+-dependent release of [3H]-dopamine and [3H]-NA as follows: N-methyl-D-aspartate (NMDA), at 200 μm, released 3.65 ± 0.23% of the total 3H catecholamines, and this effect was inhibited by 81.2% in the presence of 1 μm MK-801; quisqualate (50 μm), S-α-amino-3-hydroxy-5-methyl-4-isoxazolopropionic acid (AMPA) (100 μm) or kainate (100 μm) released 1.57 ± 0.26%, 1.93 ± 0.17% and 2.09 ± 0.22%, of the total 3H catecholamines, respectively. 4 The ionotropic glutamate receptor agonist, AMPA, induced an increase in the [Ca2+]i which was inhibited by 58.6% in the presence of 10 μm CNQX. In contrast, the increase in [Ca2+]i due to stimulation by glutamate was not sensitive to CNQX or MK–801. 5 Nitrendipine, at 1 μm, did not inhibit the neurotransmitter release induced by AMPA, but, both 0.5 μm ω-conotoxin GVIA (μ-CgTx) and 100 nm μ-Aga IVA reduced catecholamine release to 49.03 ± 3.79% and 46.06 ± 10.51% of the control, respectively. In the presence of both toxins the release was reduced to 12.58 ± 4.64% of the control. 6 The results indicate that activation of presynaptic glutamate receptors of the NMDA and non-NMDA type induces the release of [3H]-dopamine and [3H]-NA from rat hippocampal synaptosomes and that the release induced by AMPA involves the activation of N- and P-type Ca2+ channels which allow the influx of Ca2+ that triggers the 3H catecholamines release." @default.
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• W2028734519 date "1994-12-01" @default.
• W2028734519 modified "2023-10-17" @default.
• W2028734519 title "Modulation of dopamine and noradrenaline release and of intracellular Ca2+ concentration by presynaptic glutamate receptors in hippocampus" @default.
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• W2028734519 doi "https://doi.org/10.1111/j.1476-5381.1994.tb17158.x" @default.
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