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• W2028735982 abstract "In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-alpha concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis." @default.
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• W2028735982 date "2000-11-01" @default.
• W2028735982 modified "2023-09-25" @default.
• W2028735982 title "Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood–brain barrier in an animal model of acute bacterial meningitis" @default.
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• W2028735982 doi "https://doi.org/10.1016/s0165-5728(00)00354-4" @default.
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