Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028743510> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2028743510 endingPage "333" @default.
- W2028743510 startingPage "327" @default.
- W2028743510 abstract "beta-D xylosides have been shown to have venous antithrombotic properties after simple oral administration. Therefore, the arterial antithrombotic effect of these compounds was investigated in vivo, using the experimental thrombosis model induced by laser injury. The products tested were administered orally, 4 h before the thrombosis induction. Two beta-D xylosides were tested (LF 09-0055 and LP 05-0030), either after a simple oral administration at 50, 100, 200, and 400 mg/kg, or after repetitive oral administration at 200 mg/kg twice daily during 5 days. These compounds increased significantly the number of laser shots required to induce arterial thrombosis and decreased the number of emboli and the duration of embolization. At single-dose or repeated administrations, these xylosides did not affect diluted thrombin time in platelet-poor plasma collected after thrombosis inductions. They induced a dermatan sulfate-like activity in the plasma of treated rats, as measured by heparin cofactor II-mediated thrombin inhibition assay. These data suggest that these xylosides are potent arterial antithrombotic agents after single or repetitive oral administrations. beta-D xylosides constitute a very promising therapeutic class of orally active antithrombotic drugs." @default.
- W2028743510 created "2016-06-24" @default.
- W2028743510 creator A5012232223 @default.
- W2028743510 creator A5014168458 @default.
- W2028743510 creator A5041693262 @default.
- W2028743510 creator A5053335379 @default.
- W2028743510 creator A5056999086 @default.
- W2028743510 creator A5079977345 @default.
- W2028743510 creator A5080485039 @default.
- W2028743510 creator A5086043666 @default.
- W2028743510 date "1996-08-01" @default.
- W2028743510 modified "2023-09-26" @default.
- W2028743510 title "The Arterial Antithrombotic Activity of Thioxylosides in a Rat Model of Laser-Induced Thrombosis" @default.
- W2028743510 doi "https://doi.org/10.1055/s-2007-999027" @default.
- W2028743510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8944417" @default.
- W2028743510 hasPublicationYear "1996" @default.
- W2028743510 type Work @default.
- W2028743510 sameAs 2028743510 @default.
- W2028743510 citedByCount "5" @default.
- W2028743510 countsByYear W20287435102023 @default.
- W2028743510 crossrefType "journal-article" @default.
- W2028743510 hasAuthorship W2028743510A5012232223 @default.
- W2028743510 hasAuthorship W2028743510A5014168458 @default.
- W2028743510 hasAuthorship W2028743510A5041693262 @default.
- W2028743510 hasAuthorship W2028743510A5053335379 @default.
- W2028743510 hasAuthorship W2028743510A5056999086 @default.
- W2028743510 hasAuthorship W2028743510A5079977345 @default.
- W2028743510 hasAuthorship W2028743510A5080485039 @default.
- W2028743510 hasAuthorship W2028743510A5086043666 @default.
- W2028743510 hasConcept C126322002 @default.
- W2028743510 hasConcept C150903083 @default.
- W2028743510 hasConcept C207001950 @default.
- W2028743510 hasConcept C2777015399 @default.
- W2028743510 hasConcept C2777056448 @default.
- W2028743510 hasConcept C2777292125 @default.
- W2028743510 hasConcept C2777557582 @default.
- W2028743510 hasConcept C2778041096 @default.
- W2028743510 hasConcept C2778066728 @default.
- W2028743510 hasConcept C2778162025 @default.
- W2028743510 hasConcept C2778205648 @default.
- W2028743510 hasConcept C2778261982 @default.
- W2028743510 hasConcept C2779216453 @default.
- W2028743510 hasConcept C2780011451 @default.
- W2028743510 hasConcept C2780077467 @default.
- W2028743510 hasConcept C2780868729 @default.
- W2028743510 hasConcept C2909817843 @default.
- W2028743510 hasConcept C2993802102 @default.
- W2028743510 hasConcept C42219234 @default.
- W2028743510 hasConcept C71924100 @default.
- W2028743510 hasConcept C86803240 @default.
- W2028743510 hasConcept C89560881 @default.
- W2028743510 hasConcept C98274493 @default.
- W2028743510 hasConceptScore W2028743510C126322002 @default.
- W2028743510 hasConceptScore W2028743510C150903083 @default.
- W2028743510 hasConceptScore W2028743510C207001950 @default.
- W2028743510 hasConceptScore W2028743510C2777015399 @default.
- W2028743510 hasConceptScore W2028743510C2777056448 @default.
- W2028743510 hasConceptScore W2028743510C2777292125 @default.
- W2028743510 hasConceptScore W2028743510C2777557582 @default.
- W2028743510 hasConceptScore W2028743510C2778041096 @default.
- W2028743510 hasConceptScore W2028743510C2778066728 @default.
- W2028743510 hasConceptScore W2028743510C2778162025 @default.
- W2028743510 hasConceptScore W2028743510C2778205648 @default.
- W2028743510 hasConceptScore W2028743510C2778261982 @default.
- W2028743510 hasConceptScore W2028743510C2779216453 @default.
- W2028743510 hasConceptScore W2028743510C2780011451 @default.
- W2028743510 hasConceptScore W2028743510C2780077467 @default.
- W2028743510 hasConceptScore W2028743510C2780868729 @default.
- W2028743510 hasConceptScore W2028743510C2909817843 @default.
- W2028743510 hasConceptScore W2028743510C2993802102 @default.
- W2028743510 hasConceptScore W2028743510C42219234 @default.
- W2028743510 hasConceptScore W2028743510C71924100 @default.
- W2028743510 hasConceptScore W2028743510C86803240 @default.
- W2028743510 hasConceptScore W2028743510C89560881 @default.
- W2028743510 hasConceptScore W2028743510C98274493 @default.
- W2028743510 hasIssue "04" @default.
- W2028743510 hasLocation W20287435101 @default.
- W2028743510 hasLocation W20287435102 @default.
- W2028743510 hasOpenAccess W2028743510 @default.
- W2028743510 hasPrimaryLocation W20287435101 @default.
- W2028743510 hasRelatedWork W1994999842 @default.
- W2028743510 hasRelatedWork W2001854628 @default.
- W2028743510 hasRelatedWork W2028743510 @default.
- W2028743510 hasRelatedWork W2054764246 @default.
- W2028743510 hasRelatedWork W2074885943 @default.
- W2028743510 hasRelatedWork W2090820816 @default.
- W2028743510 hasRelatedWork W2094940976 @default.
- W2028743510 hasRelatedWork W2395812085 @default.
- W2028743510 hasRelatedWork W2436615412 @default.
- W2028743510 hasRelatedWork W887677915 @default.
- W2028743510 hasVolume "22" @default.
- W2028743510 isParatext "false" @default.
- W2028743510 isRetracted "false" @default.
- W2028743510 magId "2028743510" @default.
- W2028743510 workType "article" @default.