Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028750180> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2028750180 endingPage "735" @default.
- W2028750180 startingPage "735" @default.
- W2028750180 abstract "The purpose of this study was to determine the most appropriate dialysis equilibrium method to assess liposomal gel formulations containing hydrophobic drugs, to give the most accurate indication of drug release.Loperamide hydrochloride-encapsulated liposomes, composed of L-α-phosphatidylcholine and cholesterol (molar ratio of 2:1), were prepared according to the method of dried lipid film hydration. The liposomes were incorporated into a carbopol gel (0.5%, weight/weight). The release of the drug from the nanoparticles was assessed using a number of variations of the dialysis technique, taking into account solubility parameters and formulation. Method 1 (below saturation point) and Method 2 (above saturation point) used a dilution method to evaluate how drug concentration and solubility affects the in vitro drug-release profile of loperamide hydrochloride, while Methods 3 (below saturation point) and 4 (above saturation point) evaluated how drug concentration and the gel base affect the release profile.In Method 1, the liposomes showed a rapid release of just over 60% in the first 3 hours and then a slower, sustained release to just over 70% at 24 hours. Method 2 showed a gradual, sustained release profile with the liposomes with 55% release at 24 hours. In Method 3, the liposomes showed a rapid burst release of 98% at 2 hours. In Method 4, the liposomal gel had a rapid release of 60% within 3 hours and then a more gradual, sustained release with 86% release at 24 hours. The free drug suspension in Methods 2 and 4 showed a limited release across the dialysis membrane, in comparison to Methods 1 and 3, which showed a complete release in a timely manner.This study has demonstrated that the actual method used for equilibrium dialysis plays a significant role in determining the true characteristics of a topical nanoformulation, with Method 3 providing the most accurate indication of the release of a hydrophobic drug from a topical liposomal formulation." @default.
- W2028750180 created "2016-06-24" @default.
- W2028750180 creator A5002194979 @default.
- W2028750180 date "2014-01-01" @default.
- W2028750180 modified "2023-09-29" @default.
- W2028750180 title "Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery" @default.
- W2028750180 cites W1562360349 @default.
- W2028750180 cites W156871654 @default.
- W2028750180 cites W1964843466 @default.
- W2028750180 cites W1966125363 @default.
- W2028750180 cites W1973509266 @default.
- W2028750180 cites W1990240368 @default.
- W2028750180 cites W1999003507 @default.
- W2028750180 cites W2000639801 @default.
- W2028750180 cites W2053613612 @default.
- W2028750180 cites W2053642508 @default.
- W2028750180 cites W2061869172 @default.
- W2028750180 cites W2075763558 @default.
- W2028750180 cites W2076226743 @default.
- W2028750180 cites W2165215951 @default.
- W2028750180 doi "https://doi.org/10.2147/ijn.s55805" @default.
- W2028750180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3915021" @default.
- W2028750180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24511230" @default.
- W2028750180 hasPublicationYear "2014" @default.
- W2028750180 type Work @default.
- W2028750180 sameAs 2028750180 @default.
- W2028750180 citedByCount "62" @default.
- W2028750180 countsByYear W20287501802015 @default.
- W2028750180 countsByYear W20287501802016 @default.
- W2028750180 countsByYear W20287501802017 @default.
- W2028750180 countsByYear W20287501802018 @default.
- W2028750180 countsByYear W20287501802019 @default.
- W2028750180 countsByYear W20287501802020 @default.
- W2028750180 countsByYear W20287501802021 @default.
- W2028750180 countsByYear W20287501802022 @default.
- W2028750180 countsByYear W20287501802023 @default.
- W2028750180 crossrefType "journal-article" @default.
- W2028750180 hasAuthorship W2028750180A5002194979 @default.
- W2028750180 hasBestOaLocation W20287501801 @default.
- W2028750180 hasConcept C126322002 @default.
- W2028750180 hasConcept C155574463 @default.
- W2028750180 hasConcept C178790620 @default.
- W2028750180 hasConcept C185154212 @default.
- W2028750180 hasConcept C185592680 @default.
- W2028750180 hasConcept C199091049 @default.
- W2028750180 hasConcept C2777573665 @default.
- W2028750180 hasConcept C2779802037 @default.
- W2028750180 hasConcept C2779820397 @default.
- W2028750180 hasConcept C2780035454 @default.
- W2028750180 hasConcept C41625074 @default.
- W2028750180 hasConcept C43617362 @default.
- W2028750180 hasConcept C55493867 @default.
- W2028750180 hasConcept C71924100 @default.
- W2028750180 hasConcept C77281830 @default.
- W2028750180 hasConcept C98274493 @default.
- W2028750180 hasConceptScore W2028750180C126322002 @default.
- W2028750180 hasConceptScore W2028750180C155574463 @default.
- W2028750180 hasConceptScore W2028750180C178790620 @default.
- W2028750180 hasConceptScore W2028750180C185154212 @default.
- W2028750180 hasConceptScore W2028750180C185592680 @default.
- W2028750180 hasConceptScore W2028750180C199091049 @default.
- W2028750180 hasConceptScore W2028750180C2777573665 @default.
- W2028750180 hasConceptScore W2028750180C2779802037 @default.
- W2028750180 hasConceptScore W2028750180C2779820397 @default.
- W2028750180 hasConceptScore W2028750180C2780035454 @default.
- W2028750180 hasConceptScore W2028750180C41625074 @default.
- W2028750180 hasConceptScore W2028750180C43617362 @default.
- W2028750180 hasConceptScore W2028750180C55493867 @default.
- W2028750180 hasConceptScore W2028750180C71924100 @default.
- W2028750180 hasConceptScore W2028750180C77281830 @default.
- W2028750180 hasConceptScore W2028750180C98274493 @default.
- W2028750180 hasLocation W20287501801 @default.
- W2028750180 hasLocation W20287501802 @default.
- W2028750180 hasLocation W20287501803 @default.
- W2028750180 hasLocation W20287501804 @default.
- W2028750180 hasLocation W20287501805 @default.
- W2028750180 hasLocation W20287501806 @default.
- W2028750180 hasOpenAccess W2028750180 @default.
- W2028750180 hasPrimaryLocation W20287501801 @default.
- W2028750180 hasRelatedWork W2028750180 @default.
- W2028750180 hasRelatedWork W2043136003 @default.
- W2028750180 hasRelatedWork W2260748129 @default.
- W2028750180 hasRelatedWork W2506563335 @default.
- W2028750180 hasRelatedWork W2892152679 @default.
- W2028750180 hasRelatedWork W2905111812 @default.
- W2028750180 hasRelatedWork W2948450196 @default.
- W2028750180 hasRelatedWork W2952743768 @default.
- W2028750180 hasRelatedWork W3091612383 @default.
- W2028750180 hasRelatedWork W4303182829 @default.
- W2028750180 isParatext "false" @default.
- W2028750180 isRetracted "false" @default.
- W2028750180 magId "2028750180" @default.
- W2028750180 workType "article" @default.