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- W2028751490 abstract "We demonstrate in this paper that bupivacaine, a local anesthetic, can act alone as an uncoupler of rat liver mitochondria. It stimulates state 4 respiration, induces a swelling in potassium acetate (in the presence of valinomycin), and collapses the transmembrane potential. Lidocaine, another local anesthetic, requires the presence of a lipophilic anion such as TPB − to produce the same effects. TPB − can also reinforce the action of bupivacaine. These differences in action of the two local anesthetics can be explained by the difference in their liposolubility." @default.
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- W2028751490 date "1987-12-21" @default.
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- W2028751490 title "Uncoupling effects of local anesthetics on rat liver mitochondria" @default.
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- W2028751490 doi "https://doi.org/10.1016/0014-5793(87)80554-9" @default.
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