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- W2028751775 endingPage "634" @default.
- W2028751775 startingPage "628" @default.
- W2028751775 abstract "Since the characterization of genes encoding Ser/Thr-kinases and Tyr-kinases in bacteria, in 1991 and 1997, respectively, a growing body of evidence has been reported showing the important role of these enzymes in the regulation of bacterial physiology. While most Ser/Thr-kinases share structural similarity with their eukaryotic counterparts, it seems that bacteria have developed their own Tyr-kinases to catalyze protein phosphorylation on tyrosine. Different types of Tyr-kinases have been identified in bacteria and a large number of them are similar to ATP-binding proteins with Walker motifs. These enzymes have been grouped in the same family (BY-kinases) and the crystal structures of two of them have been recently characterized. Phosphoproteome analysis suggest that BY-kinases are involved in several cellular processes and to date, the best-characterized role of BY-kinases concerns the control of extracellular polysaccharide synthesis. Knowing the role of these compounds in the virulence of bacterial pathogens, BY-kinases can be considered as promising targets to combat some diseases. Here, we review the current knowledge on BY-kinases and discuss their potential for the development of new antibiotics." @default.
- W2028751775 created "2016-06-24" @default.
- W2028751775 creator A5008857641 @default.
- W2028751775 creator A5028692767 @default.
- W2028751775 creator A5082790207 @default.
- W2028751775 date "2010-03-01" @default.
- W2028751775 modified "2023-09-30" @default.
- W2028751775 title "Bacterial tyrosine-kinases: Structure–function analysis and therapeutic potential" @default.
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- W2028751775 doi "https://doi.org/10.1016/j.bbapap.2009.08.018" @default.
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