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• W2028752011 abstract "We show that, after removal of the nascent polypeptide-associated complex (NAC) from ribosome-associated nascent chains, ribosomes synthesizing proteins lacking signal peptides are efficiently targeted to the endoplasmic reticulum (ER) membrane. After this mistargeting, translocation across the ER membrane occurs, albeit less efficiently than for a nascent secretory polypeptide, perhaps because the signal peptide is needed to catalyze the opening of the translocation pore. The mistargeting was prevented by the addition of purified NAC and was shown not to be mediated by the signal recognition particle and its receptor. Instead, it appears to be a consequence of the intrinsic affinity of ribosomes for membrane binding sites, since it can be blocked by competing ribosomes that lack associated nascent polypeptides. We propose that, when bound to a signalless ribosome-associated nascent polypeptide, NAC sterically blocks the site in the ribosome for membrane binding." @default.
• W2028752011 created "2016-06-24" @default.
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• W2028752011 date "1995-06-06" @default.
• W2028752011 modified "2023-09-30" @default.
• W2028752011 title "Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum." @default.
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• W2028752011 doi "https://doi.org/10.1073/pnas.92.12.5411" @default.
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