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• W2028756812 abstract "Abstract Purpose To investigate the effect of transcytolemmal water exchange on the dynamic contrast‐enhanced (DCE) T 1 ‐weighted MRI of human squamous cell carcinomas of the head and neck (HNSCC). Materials and Methods Nine patients with HNSCC nodal metastasis underwent pretreatment DCE‐MRI with a temporal resolution of 2.5 seconds and a spatial resolution of 1 mm × 1 mm × 5 mm at 1.5T. We used two pharmacokinetic models for data analysis: generalized kinetic model (GKM) without considering transcytolemmal water exchange and the shutter‐speed model (SSM), based on a two‐site exchange model for transcytolemmal water exchange. The results were compared in three subgroups of voxels in the tumor depending on the level of contrast enhancement. Results SSM was found to be a better fit for more than 75% of pixels of all subjects ( P < 0.01) in terms of residual size and Bayesian information criterion (BIC). For all three subgroups based on the contrast enhancement, the median K trans values of SSM were 42% to 55% higher than those of GKM and the median v e values of SSM were 116% to 176% larger than those of GKM. The median K trans and v e of two models were found significantly different ( P < 0.01). The median τ i measured by SSM were from 211 to 364 msec. Conclusion The effect of transcytolemmal water exchange is an important factor that needs to be incorporated for adequate modeling of contrast enhancement dynamics measured by MRI of HNSCC. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc." @default.
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• W2028756812 date "2007-10-29" @default.
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• W2028756812 title "Transcytolemmal water exchange in pharmacokinetic analysis of dynamic contrast-enhanced MRI data in squamous cell carcinoma of the head and neck" @default.
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• W2028756812 doi "https://doi.org/10.1002/jmri.21207" @default.
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