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- W2028757587 abstract "Searching for new organophosphorus compounds with minimum effects on acetylcholinesterase of non-target organism especially mammals has gained an increased attention in the public concern. In this effort, the effects of some recently introduced O-ethyl phosphoramidates and benzo-1,3,2-dioxaphospholenes on rat acetylcholinesterase in different tissues have been evaluated in vivo and compared with the effects of fenitrothion, a commercial pesticide with reported moderate toxicity to mammals. The tested compounds were introduced orally in a single dose of 85 mg/kg body weight. Results indicated that the tested phosphoramidates lowered the enzyme activity to 54–69, 36–71 and 70–76% of its normal activity in serum, liver and brain, respectively. Meanwhile, the enzyme activity was depressed by fenitrothion to 11, 2 and 11% in the mentioned organs respectively. The lower anticholinesterase activity of the examined phosphoramidates than that of fenitrothion was attributed to their low hydrophobicity and low elect..." @default.
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- W2028757587 date "2004-01-01" @default.
- W2028757587 modified "2023-09-25" @default.
- W2028757587 title "Inhibition and recovery of serum, liver and brain acetylcholinesterase activities in rats exposed to new groups ofO-ethyl phosphoramidates and benzo-1,3,2-dioxaphospholenes" @default.
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- W2028757587 doi "https://doi.org/10.1080/02772240410001665562" @default.
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