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• W2028757687 abstract "APP695SWE/co + PS1/ΔE9 mice with Aβ plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP695SWE/co + PS1/ΔE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP695SWE/co + PS1/ΔE9 mice were impaired during acquisition of the hidden platform subtask and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology." @default.
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• W2028757687 date "2005-12-01" @default.
• W2028757687 modified "2023-09-26" @default.
• W2028757687 title "Exploratory activity and spatial learning in 12-month-old APP695SWE/co+PS1/ΔE9 mice with amyloid plaques" @default.
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• W2028757687 doi "https://doi.org/10.1016/j.neulet.2005.08.028" @default.
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