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- W2028762015 abstract "Pharmaceutical cocrystals are multicomponent materials containing an active pharmaceutical ingredient with another component in well‐defined stoichiometry within the same unit cell. Such cocrystals are important in drug design, particularly for improving physicochemical properties such as solubility, bioavailability, or chemical stability. Picolinic acid is an endogenous metabolite of tryptophan and is widely used for neuroprotective, immunological, and anti-proliferative effects within the body. In this paper we present cocrystallization experiments of a series of dicarboxylic acids, oxalic acid, succinic acid, dl-tartaric acid, pimelic acid, and phthalic acid, with picolinic acid. Characterization by FT-IR and Raman spectroscopy, DSC and TG/DTG analysis, and X-ray powder diffraction show that new compounds are formed, including a 1:1 picolinium tartrate monohydrate, a 2:1 monohydrate adduct of picolinic acid and oxalic acid, and a 2:1 picolinic acid–succinic acid monohydrate cocrystal." @default.
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- W2028762015 date "2013-01-01" @default.
- W2028762015 modified "2023-09-26" @default.
- W2028762015 title "Crystal growth and physical characterization of picolinic acid cocrystallized with dicarboxylic acids" @default.
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- W2028762015 doi "https://doi.org/10.1016/j.jcrysgro.2012.01.059" @default.
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