Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028772457> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2028772457 endingPage "4588" @default.
- W2028772457 startingPage "4583" @default.
- W2028772457 abstract "Recognition of peptides bound to class I major histocompatibility complex (MHC) molecules by specific receptors on T cells regulates the development and activity of the cellular immune system. We have designed and synthesized de novo cyclic peptides that incorporate PEG in the ring structure for binding to class I MHC molecules. The large PEG loops are positioned to extend out of the peptide binding site, thus creating steric effects aimed at preventing the recognition of class I MHC complexes by T-cell receptors. Peptides were synthesized and cyclized on polymer support using high molecular weight symmetrical PEG dicarboxylic acids to link the side chains of lysine residues substituted at positions 4 and 8 in the sequence of the HLA-A2-restricted human T-lymphotrophic virus type I Tax peptide. Cyclic peptides promoted the in vitro folding and assembly of HLA-A2 complexes. Thermal denaturation studies using circular dichroism spectroscopy showed that these complexes are as stable as complexes formed with antigenic peptides." @default.
- W2028772457 created "2016-06-24" @default.
- W2028772457 creator A5010803082 @default.
- W2028772457 creator A5091463526 @default.
- W2028772457 date "1996-05-14" @default.
- W2028772457 modified "2023-09-24" @default.
- W2028772457 title "Antigenic peptides containing large PEG loops designed to extend out of the HLA-A2 binding site form stable complexes with class I major histocompatibility complex molecules." @default.
- W2028772457 cites W1517190750 @default.
- W2028772457 cites W1534151635 @default.
- W2028772457 cites W1541726653 @default.
- W2028772457 cites W1555210583 @default.
- W2028772457 cites W1971141213 @default.
- W2028772457 cites W1977745542 @default.
- W2028772457 cites W1990332976 @default.
- W2028772457 cites W1995134733 @default.
- W2028772457 cites W1995138538 @default.
- W2028772457 cites W1997958416 @default.
- W2028772457 cites W2009703634 @default.
- W2028772457 cites W2026881694 @default.
- W2028772457 cites W2029993034 @default.
- W2028772457 cites W2035053418 @default.
- W2028772457 cites W2035937996 @default.
- W2028772457 cites W2053640312 @default.
- W2028772457 cites W2061117194 @default.
- W2028772457 cites W2063044288 @default.
- W2028772457 cites W2106481565 @default.
- W2028772457 cites W2128169249 @default.
- W2028772457 cites W2131363383 @default.
- W2028772457 cites W2159404298 @default.
- W2028772457 cites W2176905394 @default.
- W2028772457 doi "https://doi.org/10.1073/pnas.93.10.4583" @default.
- W2028772457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39320" @default.
- W2028772457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8643447" @default.
- W2028772457 hasPublicationYear "1996" @default.
- W2028772457 type Work @default.
- W2028772457 sameAs 2028772457 @default.
- W2028772457 citedByCount "22" @default.
- W2028772457 countsByYear W20287724572016 @default.
- W2028772457 crossrefType "journal-article" @default.
- W2028772457 hasAuthorship W2028772457A5010803082 @default.
- W2028772457 hasAuthorship W2028772457A5091463526 @default.
- W2028772457 hasBestOaLocation W20287724571 @default.
- W2028772457 hasConcept C104317684 @default.
- W2028772457 hasConcept C124790011 @default.
- W2028772457 hasConcept C133571119 @default.
- W2028772457 hasConcept C147483822 @default.
- W2028772457 hasConcept C178790620 @default.
- W2028772457 hasConcept C179303850 @default.
- W2028772457 hasConcept C185592680 @default.
- W2028772457 hasConcept C188280979 @default.
- W2028772457 hasConcept C203014093 @default.
- W2028772457 hasConcept C207936829 @default.
- W2028772457 hasConcept C2779281246 @default.
- W2028772457 hasConcept C32909587 @default.
- W2028772457 hasConcept C55493867 @default.
- W2028772457 hasConcept C71240020 @default.
- W2028772457 hasConcept C86803240 @default.
- W2028772457 hasConceptScore W2028772457C104317684 @default.
- W2028772457 hasConceptScore W2028772457C124790011 @default.
- W2028772457 hasConceptScore W2028772457C133571119 @default.
- W2028772457 hasConceptScore W2028772457C147483822 @default.
- W2028772457 hasConceptScore W2028772457C178790620 @default.
- W2028772457 hasConceptScore W2028772457C179303850 @default.
- W2028772457 hasConceptScore W2028772457C185592680 @default.
- W2028772457 hasConceptScore W2028772457C188280979 @default.
- W2028772457 hasConceptScore W2028772457C203014093 @default.
- W2028772457 hasConceptScore W2028772457C207936829 @default.
- W2028772457 hasConceptScore W2028772457C2779281246 @default.
- W2028772457 hasConceptScore W2028772457C32909587 @default.
- W2028772457 hasConceptScore W2028772457C55493867 @default.
- W2028772457 hasConceptScore W2028772457C71240020 @default.
- W2028772457 hasConceptScore W2028772457C86803240 @default.
- W2028772457 hasIssue "10" @default.
- W2028772457 hasLocation W20287724571 @default.
- W2028772457 hasLocation W20287724572 @default.
- W2028772457 hasLocation W20287724573 @default.
- W2028772457 hasLocation W20287724574 @default.
- W2028772457 hasOpenAccess W2028772457 @default.
- W2028772457 hasPrimaryLocation W20287724571 @default.
- W2028772457 hasRelatedWork W1485406210 @default.
- W2028772457 hasRelatedWork W1513146659 @default.
- W2028772457 hasRelatedWork W1995748297 @default.
- W2028772457 hasRelatedWork W2047661239 @default.
- W2028772457 hasRelatedWork W2051959131 @default.
- W2028772457 hasRelatedWork W2088049114 @default.
- W2028772457 hasRelatedWork W2375456368 @default.
- W2028772457 hasRelatedWork W3044268966 @default.
- W2028772457 hasRelatedWork W3185508373 @default.
- W2028772457 hasRelatedWork W4386193292 @default.
- W2028772457 hasVolume "93" @default.
- W2028772457 isParatext "false" @default.
- W2028772457 isRetracted "false" @default.
- W2028772457 magId "2028772457" @default.
- W2028772457 workType "article" @default.