Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028773044> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2028773044 endingPage "78" @default.
- W2028773044 startingPage "63" @default.
- W2028773044 abstract "Optimal monoclonal antibody-mediated immunotherapy requires the identification of tumor-restricted cell surface antigens. We have identified and partially characterized 5 new monoclonal antibodies generated against malignant astrocytoma, medulloblastoma, neuroblastoma and melanoma which were used to define 5 neuroectodermal tumor antigenic systems. CNT/1 identifies a 57-kDa, heat-stable, trypsin-sensitive neuroblastoma surface antigen, which is expressed intracellularly in many malignant gliomas, medulloblastomas, ependymomas, breast and ovarian carcinomas. CNT/2 reacts with a 130-kDa, heat-labile, trypsin- and neuraminidase-resistant antigen restricted to low-grade astrocytomas and malignant gliomas. CNT/11 reacts with a 70-kDa, heat-labile, trypsin-sensitive antigen coded for by a gene on chromosome 12, and is restricted to astrocytomas, neuroblastomas and sarcomas. CNT/8 identifies a heat-labile, trypsin-sensitive antigen whose gene has been localized to chromosome 15 and is expressed by neuroectodermal and mesodermally derived tumors and few epithelial cancers. The B2.6 antigen is identified only in terms of serologic reactivity with a subset of cultured astrocytomas and melanomas. Neuroectodermal tumor-associated antigens may be categorized as lineage-consistent, lineage-independent and putatively tumor-restricted in their expression. These restricted antibodies may be potentially useful reagents to consider for monoclonal antibody-mediated immunotherapy of CNS neoplasms." @default.
- W2028773044 created "2016-06-24" @default.
- W2028773044 creator A5004840192 @default.
- W2028773044 creator A5023774558 @default.
- W2028773044 creator A5058982388 @default.
- W2028773044 creator A5061181330 @default.
- W2028773044 creator A5063449712 @default.
- W2028773044 creator A5065795175 @default.
- W2028773044 creator A5089344430 @default.
- W2028773044 date "1989-01-01" @default.
- W2028773044 modified "2023-10-01" @default.
- W2028773044 title "Five novel cell surface antigens of CNS neoplasms" @default.
- W2028773044 cites W1979795014 @default.
- W2028773044 cites W2008442531 @default.
- W2028773044 cites W2013804264 @default.
- W2028773044 cites W2017230089 @default.
- W2028773044 cites W2055499537 @default.
- W2028773044 cites W2068968368 @default.
- W2028773044 cites W2073657532 @default.
- W2028773044 cites W2089507964 @default.
- W2028773044 cites W2131706101 @default.
- W2028773044 doi "https://doi.org/10.1016/0022-510x(89)90007-5" @default.
- W2028773044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2926443" @default.
- W2028773044 hasPublicationYear "1989" @default.
- W2028773044 type Work @default.
- W2028773044 sameAs 2028773044 @default.
- W2028773044 citedByCount "12" @default.
- W2028773044 crossrefType "journal-article" @default.
- W2028773044 hasAuthorship W2028773044A5004840192 @default.
- W2028773044 hasAuthorship W2028773044A5023774558 @default.
- W2028773044 hasAuthorship W2028773044A5058982388 @default.
- W2028773044 hasAuthorship W2028773044A5061181330 @default.
- W2028773044 hasAuthorship W2028773044A5063449712 @default.
- W2028773044 hasAuthorship W2028773044A5065795175 @default.
- W2028773044 hasAuthorship W2028773044A5089344430 @default.
- W2028773044 hasConcept C142724271 @default.
- W2028773044 hasConcept C147483822 @default.
- W2028773044 hasConcept C153911025 @default.
- W2028773044 hasConcept C159654299 @default.
- W2028773044 hasConcept C203014093 @default.
- W2028773044 hasConcept C204232928 @default.
- W2028773044 hasConcept C2775842971 @default.
- W2028773044 hasConcept C2776715637 @default.
- W2028773044 hasConcept C2777658100 @default.
- W2028773044 hasConcept C2777701055 @default.
- W2028773044 hasConcept C2778227246 @default.
- W2028773044 hasConcept C2778880634 @default.
- W2028773044 hasConcept C2780789225 @default.
- W2028773044 hasConcept C502942594 @default.
- W2028773044 hasConcept C542903549 @default.
- W2028773044 hasConcept C54355233 @default.
- W2028773044 hasConcept C71924100 @default.
- W2028773044 hasConcept C81885089 @default.
- W2028773044 hasConcept C86803240 @default.
- W2028773044 hasConcept C8891405 @default.
- W2028773044 hasConceptScore W2028773044C142724271 @default.
- W2028773044 hasConceptScore W2028773044C147483822 @default.
- W2028773044 hasConceptScore W2028773044C153911025 @default.
- W2028773044 hasConceptScore W2028773044C159654299 @default.
- W2028773044 hasConceptScore W2028773044C203014093 @default.
- W2028773044 hasConceptScore W2028773044C204232928 @default.
- W2028773044 hasConceptScore W2028773044C2775842971 @default.
- W2028773044 hasConceptScore W2028773044C2776715637 @default.
- W2028773044 hasConceptScore W2028773044C2777658100 @default.
- W2028773044 hasConceptScore W2028773044C2777701055 @default.
- W2028773044 hasConceptScore W2028773044C2778227246 @default.
- W2028773044 hasConceptScore W2028773044C2778880634 @default.
- W2028773044 hasConceptScore W2028773044C2780789225 @default.
- W2028773044 hasConceptScore W2028773044C502942594 @default.
- W2028773044 hasConceptScore W2028773044C542903549 @default.
- W2028773044 hasConceptScore W2028773044C54355233 @default.
- W2028773044 hasConceptScore W2028773044C71924100 @default.
- W2028773044 hasConceptScore W2028773044C81885089 @default.
- W2028773044 hasConceptScore W2028773044C86803240 @default.
- W2028773044 hasConceptScore W2028773044C8891405 @default.
- W2028773044 hasIssue "1" @default.
- W2028773044 hasLocation W20287730441 @default.
- W2028773044 hasLocation W20287730442 @default.
- W2028773044 hasOpenAccess W2028773044 @default.
- W2028773044 hasPrimaryLocation W20287730441 @default.
- W2028773044 hasRelatedWork W2051983598 @default.
- W2028773044 hasRelatedWork W2064089409 @default.
- W2028773044 hasRelatedWork W2073282260 @default.
- W2028773044 hasRelatedWork W2123042378 @default.
- W2028773044 hasRelatedWork W2254944297 @default.
- W2028773044 hasRelatedWork W2368460920 @default.
- W2028773044 hasRelatedWork W2372963302 @default.
- W2028773044 hasRelatedWork W2380360044 @default.
- W2028773044 hasRelatedWork W2409634333 @default.
- W2028773044 hasRelatedWork W227218597 @default.
- W2028773044 hasVolume "89" @default.
- W2028773044 isParatext "false" @default.
- W2028773044 isRetracted "false" @default.
- W2028773044 magId "2028773044" @default.
- W2028773044 workType "article" @default.