FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028774417> ?p ?o ?g. }

• W2028774417 endingPage "744" @default.
• W2028774417 startingPage "737" @default.
• W2028774417 abstract "Summary: Purpose: Valproic acid (VPA), one of the widely used antiepileptic drugs (AEDs), was recently found to inhibit histone deacetylases (HDACs). HDAC inhibitors of a wide range of structures, such as hydroxamic acids, carboxylic acids, and cyclic tetrapeptides, have various effects on transformed and nontransformed cells, including neuromodulation and neuroprotection. The aim of this study was to assess comparatively the activity of traditional and newer AEDs as HDAC inhibitors. Methods: After incubation of HeLa cells with the tested AEDs, histone hyperacetylation was assessed by immunoblotting with an antibody specific to acetylated histone H4. Direct HDAC inhibition by AEDs was estimated by using HeLa nuclear extract as an HDACs source and an acetylated lysine substrate. Results: We found that in addition to VPA, topiramate (TPM) inhibited HDACs with apparent K i values of 2.22 ± 0.67 m M . Although levetiracetam (LEV) had no direct effect on HDACs, its major carboxylic acid metabolite in humans, 2‐pyrrolidinone‐ n ‐butyric acid (PBA), inhibited HDACs with K i values of 2.25 ± 0.78 m M . The AEDs LEV, phenobarbital, phenytoin, carbamazepine, ethosuximide, gabapentin, and vigabatrin did not inhibit HDACs. The compounds that directly inhibited HDACs also induced the accumulation of acetylated histone H4 in HeLa cells. The effects of TPM and PBA on histone acetylation were significant at 0.25 m M and 1 m M , respectively. Conclusions: We found that in addition to VPA, the newer AED TPM and the major metabolite of LEV, PBA, are able to induce histone hyperacetylation in human cells, although with lower potencies than VPA." @default.
• W2028774417 created "2016-06-24" @default.
• W2028774417 creator A5000428891 @default.
• W2028774417 creator A5001346835 @default.
• W2028774417 creator A5040526869 @default.
• W2028774417 creator A5041344853 @default.
• W2028774417 creator A5053975170 @default.
• W2028774417 creator A5089448145 @default.
• W2028774417 date "2004-06-28" @default.
• W2028774417 modified "2023-10-16" @default.
• W2028774417 title "The Activity of Antiepileptic Drugs as Histone Deacetylase Inhibitors" @default.
• W2028774417 cites W138633729 @default.
• W2028774417 cites W1503830589 @default.
• W2028774417 cites W1599248432 @default.
• W2028774417 cites W1643390591 @default.
• W2028774417 cites W1775749144 @default.
• W2028774417 cites W1965538235 @default.
• W2028774417 cites W1971334707 @default.
• W2028774417 cites W1971621147 @default.
• W2028774417 cites W1977010911 @default.
• W2028774417 cites W1977831138 @default.
• W2028774417 cites W1982282930 @default.
• W2028774417 cites W2013407710 @default.
• W2028774417 cites W2021860877 @default.
• W2028774417 cites W2022285476 @default.
• W2028774417 cites W2031906032 @default.
• W2028774417 cites W2044950358 @default.
• W2028774417 cites W2057552859 @default.
• W2028774417 cites W2069789486 @default.
• W2028774417 cites W2070468167 @default.
• W2028774417 cites W2071981322 @default.
• W2028774417 cites W2097195800 @default.
• W2028774417 cites W2098249941 @default.
• W2028774417 cites W2104210885 @default.
• W2028774417 cites W2105180380 @default.
• W2028774417 cites W2107733280 @default.
• W2028774417 cites W2111843532 @default.
• W2028774417 cites W2117691193 @default.
• W2028774417 cites W2125601003 @default.
• W2028774417 cites W2126762925 @default.
• W2028774417 cites W2135830745 @default.
• W2028774417 cites W2165455805 @default.
• W2028774417 cites W2784906153 @default.
• W2028774417 doi "https://doi.org/10.1111/j.0013-9580.2004.00104.x" @default.
• W2028774417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15230695" @default.
• W2028774417 hasPublicationYear "2004" @default.
• W2028774417 type Work @default.
• W2028774417 sameAs 2028774417 @default.
• W2028774417 citedByCount "177" @default.
• W2028774417 countsByYear W20287744172012 @default.
• W2028774417 countsByYear W20287744172013 @default.
• W2028774417 countsByYear W20287744172014 @default.
• W2028774417 countsByYear W20287744172015 @default.
• W2028774417 countsByYear W20287744172016 @default.
• W2028774417 countsByYear W20287744172017 @default.
• W2028774417 countsByYear W20287744172018 @default.
• W2028774417 countsByYear W20287744172019 @default.
• W2028774417 countsByYear W20287744172020 @default.
• W2028774417 countsByYear W20287744172021 @default.
• W2028774417 countsByYear W20287744172022 @default.
• W2028774417 countsByYear W20287744172023 @default.
• W2028774417 crossrefType "journal-article" @default.
• W2028774417 hasAuthorship W2028774417A5000428891 @default.
• W2028774417 hasAuthorship W2028774417A5001346835 @default.
• W2028774417 hasAuthorship W2028774417A5040526869 @default.
• W2028774417 hasAuthorship W2028774417A5041344853 @default.
• W2028774417 hasAuthorship W2028774417A5053975170 @default.
• W2028774417 hasAuthorship W2028774417A5089448145 @default.
• W2028774417 hasConcept C104317684 @default.
• W2028774417 hasConcept C119157956 @default.
• W2028774417 hasConcept C169760540 @default.
• W2028774417 hasConcept C185592680 @default.
• W2028774417 hasConcept C2776202225 @default.
• W2028774417 hasConcept C2777172819 @default.
• W2028774417 hasConcept C2777332695 @default.
• W2028774417 hasConcept C2777477808 @default.
• W2028774417 hasConcept C2778186239 @default.
• W2028774417 hasConcept C2778305200 @default.
• W2028774417 hasConcept C55493867 @default.
• W2028774417 hasConcept C64927066 @default.
• W2028774417 hasConcept C86803240 @default.
• W2028774417 hasConcept C98274493 @default.
• W2028774417 hasConceptScore W2028774417C104317684 @default.
• W2028774417 hasConceptScore W2028774417C119157956 @default.
• W2028774417 hasConceptScore W2028774417C169760540 @default.
• W2028774417 hasConceptScore W2028774417C185592680 @default.
• W2028774417 hasConceptScore W2028774417C2776202225 @default.
• W2028774417 hasConceptScore W2028774417C2777172819 @default.
• W2028774417 hasConceptScore W2028774417C2777332695 @default.
• W2028774417 hasConceptScore W2028774417C2777477808 @default.
• W2028774417 hasConceptScore W2028774417C2778186239 @default.
• W2028774417 hasConceptScore W2028774417C2778305200 @default.
• W2028774417 hasConceptScore W2028774417C55493867 @default.
• W2028774417 hasConceptScore W2028774417C64927066 @default.
• W2028774417 hasConceptScore W2028774417C86803240 @default.
• W2028774417 hasConceptScore W2028774417C98274493 @default.
• W2028774417 hasIssue "7" @default.
• W2028774417 hasLocation W20287744171 @default.

• next