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- W2028776429 abstract "Abstract In the present study, we established and characterized an animal model of vulnerability to repeated stress. We found that control Sprague–Dawley (SD) rats showed a gradual decrease in the HPA axis response following 14 days of repeated restraint stress, whereas Fischer 344 (F344) rats did not show such HPA axis habituation. Similar habituation was observed in the expression of c‐fos mRNA, corticotropin‐releasing hormone hnRNA, and phospho‐CREB and phospho‐ERK proteins in the hypothalamic paraventricular nucleus (PVN) of SD rats, but not in the F344 rats. In addition, repeatedly restrained F344 rats exhibited decreased cell proliferation in the dentate gyrus of the hippocampus and increased anxiety‐related behaviours, while repeatedly restrained SD rats exhibited a selective enhancement of hippocampal cell proliferation in the ventral area. Moreover, we found a lower expression of glucocorticoid receptor (GR) protein, but not mRNA, in the PVN of F344 rats compared to SD rats. We also identified that microRNA (miR)‐18a inhibited translation of GR mRNA in cultured neuronal cells and that increased expression of miR‐18a in the PVN was observed in F344 rats compared with SD rats. These strain differences in GR protein levels were not found in the hippocampus and prefrontal cortex, and the expression of miR‐18a was much lower in these brain regions than in the PVN. Our results suggest that F344 rats could be a useful animal model for studying vulnerability to repeated stress, and that miR‐18a‐mediated down‐regulation of GR translation may be an important factor to be considered in susceptibility to stress‐related disorders." @default.
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- W2028776429 date "2008-04-25" @default.
- W2028776429 modified "2023-10-17" @default.
- W2028776429 title "Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor" @default.
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- W2028776429 cites W2035897490 @default.
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- W2028776429 cites W2123923673 @default.
- W2028776429 cites W2124036196 @default.
- W2028776429 cites W2130685024 @default.
- W2028776429 cites W2141682070 @default.
- W2028776429 cites W2148239264 @default.
- W2028776429 cites W2148316222 @default.
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- W2028776429 cites W2163199119 @default.
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- W2028776429 doi "https://doi.org/10.1111/j.1460-9568.2008.06218.x" @default.
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