FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028777730> ?p ?o ?g. }

• W2028777730 endingPage "260" @default.
• W2028777730 startingPage "253" @default.
• W2028777730 abstract "Antisense oligodeoxynucleotides (ODN) were used to investigate the supraspinal antinociceptive effects of endomorphin-1, an endogenous peptide whose analgesic profile suggests that it is a ligand at the mu-opioid receptor. To selectively restrict the expression of this receptor, five ODN targeting distinct exons of the gene sequence were injected subchronically by the intracerebroventricular route (i.c.v.) into mice. The antinociception induced by endomorphin-1 was greatly reduced in animals receiving the ODN directed to nucleotides 677′697, which code for a sequence located on the second extracellular loop of the mu receptor. ODN-μun, one of the two antisense ODN directed to exon 1, also impaired endomorphin-1 antinociception. ODN targeting exons 2 and 4 were totally inactive. In contrast, all five ODN blocked the antinociception induced by morphine and β-casomorphin. The analgesic potency of endomorphin-1, morphine, and β-casomorphin remained unaltered by administration of an ODN to nucleotides 29′46 of the murine delta-opioid receptor gene sequence of a random-sequence ODN. This suggest the existence of diverse molecular forms for the mu-opioid receptor that mediate the antinociceptive effects of endomorphin-1 and morphine/β-casomorphin." @default.
• W2028777730 created "2016-06-24" @default.
• W2028777730 creator A5000293437 @default.
• W2028777730 creator A5019701584 @default.
• W2028777730 creator A5051380834 @default.
• W2028777730 creator A5090552628 @default.
• W2028777730 date "1999-06-01" @default.
• W2028777730 modified "2023-10-18" @default.
• W2028777730 title "Antisense Oligodeoxynucleotides Targeting Distinct Exons of the Cloned mu-Opioid Receptor Distinguish Between Endomorphin-1 and Morphine Supraspinal Antinociception in Mice" @default.
• W2028777730 cites W1819235616 @default.
• W2028777730 cites W1883072390 @default.
• W2028777730 cites W1893651774 @default.
• W2028777730 cites W1894118272 @default.
• W2028777730 cites W1969909813 @default.
• W2028777730 cites W1970702889 @default.
• W2028777730 cites W1975262853 @default.
• W2028777730 cites W1980422398 @default.
• W2028777730 cites W1989381799 @default.
• W2028777730 cites W1991514368 @default.
• W2028777730 cites W1993468298 @default.
• W2028777730 cites W2005432373 @default.
• W2028777730 cites W2006247400 @default.
• W2028777730 cites W2010716912 @default.
• W2028777730 cites W2013907129 @default.
• W2028777730 cites W2019290569 @default.
• W2028777730 cites W2026787509 @default.
• W2028777730 cites W2026919416 @default.
• W2028777730 cites W2030787536 @default.
• W2028777730 cites W2033492865 @default.
• W2028777730 cites W2038618141 @default.
• W2028777730 cites W2039764726 @default.
• W2028777730 cites W2045112376 @default.
• W2028777730 cites W2050323310 @default.
• W2028777730 cites W2054119130 @default.
• W2028777730 cites W2054615424 @default.
• W2028777730 cites W2072971490 @default.
• W2028777730 cites W2079803201 @default.
• W2028777730 cites W2087569537 @default.
• W2028777730 cites W2115551883 @default.
• W2028777730 cites W2135662596 @default.
• W2028777730 cites W2140257707 @default.
• W2028777730 cites W2154943301 @default.
• W2028777730 cites W2159380570 @default.
• W2028777730 cites W2414586066 @default.
• W2028777730 cites W2787012987 @default.
• W2028777730 cites W2142017226 @default.
• W2028777730 doi "https://doi.org/10.1089/oli.1.1999.9.253" @default.
• W2028777730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10435750" @default.
• W2028777730 hasPublicationYear "1999" @default.
• W2028777730 type Work @default.
• W2028777730 sameAs 2028777730 @default.
• W2028777730 citedByCount "17" @default.
• W2028777730 countsByYear W20287777302014 @default.
• W2028777730 crossrefType "journal-article" @default.
• W2028777730 hasAuthorship W2028777730A5000293437 @default.
• W2028777730 hasAuthorship W2028777730A5019701584 @default.
• W2028777730 hasAuthorship W2028777730A5051380834 @default.
• W2028777730 hasAuthorship W2028777730A5090552628 @default.
• W2028777730 hasConcept C104317684 @default.
• W2028777730 hasConcept C14397066 @default.
• W2028777730 hasConcept C153911025 @default.
• W2028777730 hasConcept C15490471 @default.
• W2028777730 hasConcept C170493617 @default.
• W2028777730 hasConcept C185592680 @default.
• W2028777730 hasConcept C2777389121 @default.
• W2028777730 hasConcept C2779886867 @default.
• W2028777730 hasConcept C2781063702 @default.
• W2028777730 hasConcept C36823959 @default.
• W2028777730 hasConcept C55493867 @default.
• W2028777730 hasConcept C86803240 @default.
• W2028777730 hasConcept C88016717 @default.
• W2028777730 hasConcept C98274493 @default.
• W2028777730 hasConceptScore W2028777730C104317684 @default.
• W2028777730 hasConceptScore W2028777730C14397066 @default.
• W2028777730 hasConceptScore W2028777730C153911025 @default.
• W2028777730 hasConceptScore W2028777730C15490471 @default.
• W2028777730 hasConceptScore W2028777730C170493617 @default.
• W2028777730 hasConceptScore W2028777730C185592680 @default.
• W2028777730 hasConceptScore W2028777730C2777389121 @default.
• W2028777730 hasConceptScore W2028777730C2779886867 @default.
• W2028777730 hasConceptScore W2028777730C2781063702 @default.
• W2028777730 hasConceptScore W2028777730C36823959 @default.
• W2028777730 hasConceptScore W2028777730C55493867 @default.
• W2028777730 hasConceptScore W2028777730C86803240 @default.
• W2028777730 hasConceptScore W2028777730C88016717 @default.
• W2028777730 hasConceptScore W2028777730C98274493 @default.
• W2028777730 hasIssue "3" @default.
• W2028777730 hasLocation W20287777301 @default.
• W2028777730 hasLocation W20287777302 @default.
• W2028777730 hasOpenAccess W2028777730 @default.
• W2028777730 hasPrimaryLocation W20287777301 @default.
• W2028777730 hasRelatedWork W1894118272 @default.
• W2028777730 hasRelatedWork W1912930376 @default.
• W2028777730 hasRelatedWork W1926750449 @default.
• W2028777730 hasRelatedWork W1975262853 @default.
• W2028777730 hasRelatedWork W1984519562 @default.
• W2028777730 hasRelatedWork W1990336277 @default.
• W2028777730 hasRelatedWork W2011973300 @default.

• next