FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028777794> ?p ?o ?g. }

• W2028777794 endingPage "586" @default.
• W2028777794 startingPage "574" @default.
• W2028777794 abstract "The solution structure of a synthetic 22-amino acid peptide (P1) corresponding to the extreme C-terminal end and one of the F-actin binding sites of villin has been determined by 1H NMR and CD spectroscopy. The structure of this peptide was compared to that of a peptide in which lysine to glutamic acid substitutions were introduced at positions 17 and 19 (P11), abolishing F-actin binding. Both peptides are largely unstructured in aqueous solution. Changes observed in the NMR and CD spectra of both peptides are consistent with alpha-helix formation in trifluoroethanol/water mixtures. A set of 189 interproton distances derived from nuclear Overhauser enhancement (NOE) measurements, 17 phi-angle constraints obtained from 3JNH alpha coupling constants, as well as about 10 N ... O distance restraints deduced from amide proton exchange kinetics with deuterium, were used for the structure determination. The three-dimensional structure of P1 and P11 is characterized by two helical regions, one extending from residues 2 to 5 and a second covering residues 7 to 17. The central fragment, ranging from Leu-7 to Leu-15, is more stable. The C-terminal residues are less structured, particularly within peptide P11. The significance of these structural results is discussed in relation to the biological activity of villin." @default.
• W2028777794 created "2016-06-24" @default.
• W2028777794 creator A5011990510 @default.
• W2028777794 creator A5033749421 @default.
• W2028777794 creator A5050086918 @default.
• W2028777794 creator A5059979662 @default.
• W2028777794 creator A5068728973 @default.
• W2028777794 creator A5072693404 @default.
• W2028777794 creator A5075879769 @default.
• W2028777794 date "2009-01-12" @default.
• W2028777794 modified "2023-09-25" @default.
• W2028777794 title "Conformational behaviour of a synthetic peptide of the C-terminus of villin that interacts with actin: an NMR, CD and simulated annealing study" @default.
• W2028777794 cites W1539339671 @default.
• W2028777794 cites W1593567129 @default.
• W2028777794 cites W1930601960 @default.
• W2028777794 cites W1963550288 @default.
• W2028777794 cites W1971251199 @default.
• W2028777794 cites W1972617251 @default.
• W2028777794 cites W1976132571 @default.
• W2028777794 cites W1976642662 @default.
• W2028777794 cites W1993844842 @default.
• W2028777794 cites W1994473228 @default.
• W2028777794 cites W1994777823 @default.
• W2028777794 cites W1997354900 @default.
• W2028777794 cites W1997624484 @default.
• W2028777794 cites W2007415752 @default.
• W2028777794 cites W2009502218 @default.
• W2028777794 cites W2019178773 @default.
• W2028777794 cites W2020861880 @default.
• W2028777794 cites W2021785626 @default.
• W2028777794 cites W2027589805 @default.
• W2028777794 cites W2036178039 @default.
• W2028777794 cites W2044815019 @default.
• W2028777794 cites W2045950270 @default.
• W2028777794 cites W2056686332 @default.
• W2028777794 cites W2057691786 @default.
• W2028777794 cites W2059392350 @default.
• W2028777794 cites W2065733938 @default.
• W2028777794 cites W2066446602 @default.
• W2028777794 cites W2074978848 @default.
• W2028777794 cites W2081359387 @default.
• W2028777794 cites W2084140416 @default.
• W2028777794 cites W2085831331 @default.
• W2028777794 cites W2088848851 @default.
• W2028777794 cites W2091400786 @default.
• W2028777794 cites W2092302879 @default.
• W2028777794 cites W2094604448 @default.
• W2028777794 cites W2094749976 @default.
• W2028777794 cites W2095450147 @default.
• W2028777794 cites W2132177601 @default.
• W2028777794 cites W2136489728 @default.
• W2028777794 cites W2149478455 @default.
• W2028777794 cites W2165982110 @default.
• W2028777794 cites W2949250147 @default.
• W2028777794 cites W4244533457 @default.
• W2028777794 doi "https://doi.org/10.1111/j.1399-3011.1995.tb01322.x" @default.
• W2028777794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7558589" @default.
• W2028777794 hasPublicationYear "2009" @default.
• W2028777794 type Work @default.
• W2028777794 sameAs 2028777794 @default.
• W2028777794 citedByCount "7" @default.
• W2028777794 crossrefType "journal-article" @default.
• W2028777794 hasAuthorship W2028777794A5011990510 @default.
• W2028777794 hasAuthorship W2028777794A5033749421 @default.
• W2028777794 hasAuthorship W2028777794A5050086918 @default.
• W2028777794 hasAuthorship W2028777794A5059979662 @default.
• W2028777794 hasAuthorship W2028777794A5068728973 @default.
• W2028777794 hasAuthorship W2028777794A5072693404 @default.
• W2028777794 hasAuthorship W2028777794A5075879769 @default.
• W2028777794 hasConcept C104317684 @default.
• W2028777794 hasConcept C119851462 @default.
• W2028777794 hasConcept C125705527 @default.
• W2028777794 hasConcept C167625842 @default.
• W2028777794 hasConcept C185592680 @default.
• W2028777794 hasConcept C19549132 @default.
• W2028777794 hasConcept C2778439535 @default.
• W2028777794 hasConcept C2779281246 @default.
• W2028777794 hasConcept C2779856020 @default.
• W2028777794 hasConcept C2781470882 @default.
• W2028777794 hasConcept C47701112 @default.
• W2028777794 hasConcept C515207424 @default.
• W2028777794 hasConcept C55493867 @default.
• W2028777794 hasConcept C66974803 @default.
• W2028777794 hasConcept C71240020 @default.
• W2028777794 hasConcept C8010536 @default.
• W2028777794 hasConceptScore W2028777794C104317684 @default.
• W2028777794 hasConceptScore W2028777794C119851462 @default.
• W2028777794 hasConceptScore W2028777794C125705527 @default.
• W2028777794 hasConceptScore W2028777794C167625842 @default.
• W2028777794 hasConceptScore W2028777794C185592680 @default.
• W2028777794 hasConceptScore W2028777794C19549132 @default.
• W2028777794 hasConceptScore W2028777794C2778439535 @default.
• W2028777794 hasConceptScore W2028777794C2779281246 @default.
• W2028777794 hasConceptScore W2028777794C2779856020 @default.
• W2028777794 hasConceptScore W2028777794C2781470882 @default.
• W2028777794 hasConceptScore W2028777794C47701112 @default.
• W2028777794 hasConceptScore W2028777794C515207424 @default.
• W2028777794 hasConceptScore W2028777794C55493867 @default.

• next