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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028778085> ?p ?o ?g. }

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• W2028778085 abstract "This paper presents a surface-based approach to inhibit the binding of proteins to Alzheimer’s-related β-amyloid (Aβ) fibrils with small molecules. It reports the idea of using an intracellular, disease-related fibril as a material whose surface can be coated with small molecules. Using an ELISA-based assay, molecular surface coatings with thioflavin T are shown to inhibit 65 ± 10% of the binding of two different anti-Aβ IgGs to Aβ fibrils. A molecular surface coating with 3,6-diamino acridine was able to inhibit 76 ± 10% of the binding of an anti-Aβ IgG to Aβ fibrils. Maximal inhibition of these protein–amyloid interactions appears in the low to mid-micromolar range of small molecule. This demonstration that molecular surface coatings can be used to attenuate the interaction of proteins with these fibrils suggests a potentially new strategy for therapeutics in neurodegenerative amyloid diseases." @default.
• W2028778085 created "2016-06-24" @default.
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• W2028778085 date "2006-02-01" @default.
• W2028778085 modified "2023-10-16" @default.
• W2028778085 title "Inhibiting protein–amyloid interactions with small molecules: A surface chemistry approach" @default.
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• W2028778085 doi "https://doi.org/10.1016/j.bmcl.2005.10.067" @default.
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