FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028778538> ?p ?o ?g. }

• W2028778538 endingPage "e0119605" @default.
• W2028778538 startingPage "e0119605" @default.
• W2028778538 abstract "Epstein-Barr virus (EBV) is a non-heritable factor that associates with multiple sclerosis (MS). However its causal relationship with the disease is still unclear. The virus establishes a complex co-existence with the host that includes regulatory influences on gene expression. Hence, if EBV contributes to the pathogenesis of MS it may do so by interacting with disease predisposing genes. To verify this hypothesis we evaluated EBV nuclear antigen 2 (EBNA2, a protein that recent works by our and other groups have implicated in disease development) binding inside MS associated genomic intervals. We found that EBNA2 binding occurs within MS susceptibility sites more than expected by chance (factor of observed vs expected overlap [O/E] = 5.392-fold, p < 2.0e-05). This remains significant after controlling for multiple genomic confounders. We then asked whether this observation is significant per se or should also be viewed in the context of other disease relevant gene-environment interactions, such as those attributable to vitamin D. We therefore verified the overlap between EBNA2 genomic occupancy and vitamin D receptor (VDR) binding sites. EBNA2 shows a striking overlap with VDR binding sites (O/E = 96.16-fold, p < 2.0e-05), even after controlling for the chromatin accessibility state of shared regions (p <0.001). Furthermore, MS susceptibility regions are preferentially targeted by both EBNA2 and VDR than by EBNA2 alone (enrichment difference = 1.722-fold, p = 0.0267). Taken together, these findings demonstrate that EBV participates in the gene-environment interactions that predispose to MS." @default.
• W2028778538 created "2016-06-24" @default.
• W2028778538 creator A5032155895 @default.
• W2028778538 creator A5043862179 @default.
• W2028778538 creator A5051032795 @default.
• W2028778538 creator A5053457002 @default.
• W2028778538 creator A5054500587 @default.
• W2028778538 creator A5054546964 @default.
• W2028778538 creator A5076117849 @default.
• W2028778538 creator A5076241090 @default.
• W2028778538 date "2015-04-08" @default.
• W2028778538 modified "2023-09-26" @default.
• W2028778538 title "EBNA2 Binds to Genomic Intervals Associated with Multiple Sclerosis and Overlaps with Vitamin D Receptor Occupancy" @default.
• W2028778538 cites W1578954095 @default.
• W2028778538 cites W1911156364 @default.
• W2028778538 cites W1971571526 @default.
• W2028778538 cites W1978837598 @default.
• W2028778538 cites W1979594866 @default.
• W2028778538 cites W2002669780 @default.
• W2028778538 cites W2012883868 @default.
• W2028778538 cites W2023743167 @default.
• W2028778538 cites W2026311933 @default.
• W2028778538 cites W2038266768 @default.
• W2028778538 cites W2045978029 @default.
• W2028778538 cites W2048417796 @default.
• W2028778538 cites W2049974174 @default.
• W2028778538 cites W2050437747 @default.
• W2028778538 cites W2064712401 @default.
• W2028778538 cites W2068549702 @default.
• W2028778538 cites W2081632246 @default.
• W2028778538 cites W2084198387 @default.
• W2028778538 cites W2087638002 @default.
• W2028778538 cites W2089219418 @default.
• W2028778538 cites W2103441770 @default.
• W2028778538 cites W2108101252 @default.
• W2028778538 cites W2112935184 @default.
• W2028778538 cites W2114978329 @default.
• W2028778538 cites W2117305974 @default.
• W2028778538 cites W2117446594 @default.
• W2028778538 cites W2123226794 @default.
• W2028778538 cites W2124413251 @default.
• W2028778538 cites W2127640118 @default.
• W2028778538 cites W2128476271 @default.
• W2028778538 cites W2132142991 @default.
• W2028778538 cites W2135403800 @default.
• W2028778538 cites W2135604027 @default.
• W2028778538 cites W2138258120 @default.
• W2028778538 cites W2141111992 @default.
• W2028778538 cites W2144448602 @default.
• W2028778538 cites W2148959055 @default.
• W2028778538 cites W2161977215 @default.
• W2028778538 cites W2171808845 @default.
• W2028778538 cites W2172006847 @default.
• W2028778538 cites W2319284141 @default.
• W2028778538 cites W3103944316 @default.
• W2028778538 doi "https://doi.org/10.1371/journal.pone.0119605" @default.
• W2028778538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4390304" @default.
• W2028778538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25853421" @default.
• W2028778538 hasPublicationYear "2015" @default.
• W2028778538 type Work @default.
• W2028778538 sameAs 2028778538 @default.
• W2028778538 citedByCount "43" @default.
• W2028778538 countsByYear W20287785382015 @default.
• W2028778538 countsByYear W20287785382016 @default.
• W2028778538 countsByYear W20287785382017 @default.
• W2028778538 countsByYear W20287785382018 @default.
• W2028778538 countsByYear W20287785382019 @default.
• W2028778538 countsByYear W20287785382020 @default.
• W2028778538 countsByYear W20287785382021 @default.
• W2028778538 countsByYear W20287785382022 @default.
• W2028778538 countsByYear W20287785382023 @default.
• W2028778538 crossrefType "journal-article" @default.
• W2028778538 hasAuthorship W2028778538A5032155895 @default.
• W2028778538 hasAuthorship W2028778538A5043862179 @default.
• W2028778538 hasAuthorship W2028778538A5051032795 @default.
• W2028778538 hasAuthorship W2028778538A5053457002 @default.
• W2028778538 hasAuthorship W2028778538A5054500587 @default.
• W2028778538 hasAuthorship W2028778538A5054546964 @default.
• W2028778538 hasAuthorship W2028778538A5076117849 @default.
• W2028778538 hasAuthorship W2028778538A5076241090 @default.
• W2028778538 hasBestOaLocation W20287785381 @default.
• W2028778538 hasConcept C104317684 @default.
• W2028778538 hasConcept C124490489 @default.
• W2028778538 hasConcept C134018914 @default.
• W2028778538 hasConcept C151730666 @default.
• W2028778538 hasConcept C179639408 @default.
• W2028778538 hasConcept C2779343474 @default.
• W2028778538 hasConcept C54355233 @default.
• W2028778538 hasConcept C86803240 @default.
• W2028778538 hasConceptScore W2028778538C104317684 @default.
• W2028778538 hasConceptScore W2028778538C124490489 @default.
• W2028778538 hasConceptScore W2028778538C134018914 @default.
• W2028778538 hasConceptScore W2028778538C151730666 @default.
• W2028778538 hasConceptScore W2028778538C179639408 @default.
• W2028778538 hasConceptScore W2028778538C2779343474 @default.
• W2028778538 hasConceptScore W2028778538C54355233 @default.
• W2028778538 hasConceptScore W2028778538C86803240 @default.
• W2028778538 hasIssue "4" @default.

• next