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• W2028778894 abstract "Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vβ6 expressing T cells in the thymus of Mtv-7+ DBA/2 (H2d) mice through negative selection. We found that in Mtv-7− BALB/c (H2d) mice, Vβ6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEYAEYAEYA [abbreviated as K5 or EYK(EYA)5]. It was therefore surprising to find that despite the deletion of Vβ6+ T cells, vigorous K5 specific T cell responses that use Vβ6 can be raised in DBA/2 mice. Sequence analysis of Vβ6 junctional diversity in K5 specific T cell lines revealed that the DBA/2 K5 repertoire compensates for the loss of most Vβ6 T cells by overusing and amplifying Vβ6+ T cells escaping central deletion and peripheral tolerization. In order to address the inability of some Vβ6 T cells to recognize Mtv-7+ we analyzed a panel of BALB/c Vβ6 expressing T cell hybridomas. This data supported the argument that certain Vβ6 junctional sequences preclude Mtv recognition and allows their escape from central deletion in DBA/2 mice. These cells are not anergic and can be activated with cognate peptide antigen in periphery. We suggest that junctional diversity at the V region of some of the T cell receptors does not allow these cells to recognize self-superantigens with high enough affinity and thus they escape negative selection in the thymus. These results for the first time provide a molecular explanation of how the immune system compensates for “hole in the repertoire” caused by deletion of the majority of T cells carrying certain V region segments." @default.
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• W2028778894 date "2010-02-01" @default.
• W2028778894 modified "2023-10-16" @default.
• W2028778894 title "Junctional diversity prevents negative selection of an antigen-specific T cell repertoire" @default.
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• W2028778894 doi "https://doi.org/10.1016/j.molimm.2009.11.006" @default.
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