Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028779612> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2028779612 endingPage "106" @default.
- W2028779612 startingPage "101" @default.
- W2028779612 abstract "The inactivation of the tumor suppressor gene p16 by methylation (p16M) has been recognized recently as an important process in the oncogenesis for a variety of carcinomas. There have been few reports of its use in lung cancer. We investigate p16M in patients with non-small cell lung cancer (NSCLC).p16M in tumor, plasma, and pleural lavage fluid from patients with resectable NSCLC were investigated by using methylation-specific polymerase chain reaction.Of the 33 patients studied, 14 (42%) had p16M tumors. There was a significant association between p16M tumors and advanced TNM staging (stage III or IV, P=0.047, Fisher exact test). Circulating p16M was identified in 2 of the 14 patients with p16M tumor and was also associated with advanced TNM staging (P=0.049). The presence of plasma p16M in NSCLC patients and in p16M tumor patients was associated with poor survival and shorter disease-free survival (P=0.0028, P=0.0039, Kaplan-Meier log rank). In addition, p16M was present in three preresectional and four postresectional lavage samples. Preresectional p16M was associated with poor survival and shorter disease-free survival (P=0.0085). p16M tumor involving the visceral pleura was significantly associated with positive p16M postresectional lavage.Positive tumor and plasma p16M indicate advanced staging in NSCLC. Patients with plasma and preresection pleural lavage p16M have shorter survival. Further research in this direction is warranted." @default.
- W2028779612 created "2016-06-24" @default.
- W2028779612 creator A5004001764 @default.
- W2028779612 creator A5010695207 @default.
- W2028779612 creator A5018917131 @default.
- W2028779612 creator A5049505870 @default.
- W2028779612 creator A5066717752 @default.
- W2028779612 creator A5071672663 @default.
- W2028779612 creator A5086804228 @default.
- W2028779612 creator A5088357606 @default.
- W2028779612 date "2002-01-17" @default.
- W2028779612 modified "2023-10-16" @default.
- W2028779612 title "Tumorp16M is a possible marker of advanced stage in non-small cell lung cancer" @default.
- W2028779612 cites W1508415075 @default.
- W2028779612 cites W1568840496 @default.
- W2028779612 cites W1977706798 @default.
- W2028779612 cites W1991702183 @default.
- W2028779612 cites W1994227693 @default.
- W2028779612 cites W1994465394 @default.
- W2028779612 cites W2009367600 @default.
- W2028779612 cites W2010837997 @default.
- W2028779612 cites W2029849434 @default.
- W2028779612 cites W2040618717 @default.
- W2028779612 cites W2070207712 @default.
- W2028779612 cites W2110511887 @default.
- W2028779612 cites W2161252269 @default.
- W2028779612 cites W4250356013 @default.
- W2028779612 doi "https://doi.org/10.1002/jso.10046" @default.
- W2028779612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11815997" @default.
- W2028779612 hasPublicationYear "2002" @default.
- W2028779612 type Work @default.
- W2028779612 sameAs 2028779612 @default.
- W2028779612 citedByCount "52" @default.
- W2028779612 countsByYear W20287796122012 @default.
- W2028779612 countsByYear W20287796122013 @default.
- W2028779612 countsByYear W20287796122014 @default.
- W2028779612 countsByYear W20287796122015 @default.
- W2028779612 countsByYear W20287796122016 @default.
- W2028779612 countsByYear W20287796122017 @default.
- W2028779612 countsByYear W20287796122018 @default.
- W2028779612 countsByYear W20287796122019 @default.
- W2028779612 countsByYear W20287796122022 @default.
- W2028779612 crossrefType "journal-article" @default.
- W2028779612 hasAuthorship W2028779612A5004001764 @default.
- W2028779612 hasAuthorship W2028779612A5010695207 @default.
- W2028779612 hasAuthorship W2028779612A5018917131 @default.
- W2028779612 hasAuthorship W2028779612A5049505870 @default.
- W2028779612 hasAuthorship W2028779612A5066717752 @default.
- W2028779612 hasAuthorship W2028779612A5071672663 @default.
- W2028779612 hasAuthorship W2028779612A5086804228 @default.
- W2028779612 hasAuthorship W2028779612A5088357606 @default.
- W2028779612 hasBestOaLocation W20287796121 @default.
- W2028779612 hasConcept C10515644 @default.
- W2028779612 hasConcept C121608353 @default.
- W2028779612 hasConcept C126322002 @default.
- W2028779612 hasConcept C142724271 @default.
- W2028779612 hasConcept C143998085 @default.
- W2028779612 hasConcept C146357865 @default.
- W2028779612 hasConcept C151730666 @default.
- W2028779612 hasConcept C2776256026 @default.
- W2028779612 hasConcept C555283112 @default.
- W2028779612 hasConcept C66339696 @default.
- W2028779612 hasConcept C71924100 @default.
- W2028779612 hasConcept C86803240 @default.
- W2028779612 hasConcept C90924648 @default.
- W2028779612 hasConceptScore W2028779612C10515644 @default.
- W2028779612 hasConceptScore W2028779612C121608353 @default.
- W2028779612 hasConceptScore W2028779612C126322002 @default.
- W2028779612 hasConceptScore W2028779612C142724271 @default.
- W2028779612 hasConceptScore W2028779612C143998085 @default.
- W2028779612 hasConceptScore W2028779612C146357865 @default.
- W2028779612 hasConceptScore W2028779612C151730666 @default.
- W2028779612 hasConceptScore W2028779612C2776256026 @default.
- W2028779612 hasConceptScore W2028779612C555283112 @default.
- W2028779612 hasConceptScore W2028779612C66339696 @default.
- W2028779612 hasConceptScore W2028779612C71924100 @default.
- W2028779612 hasConceptScore W2028779612C86803240 @default.
- W2028779612 hasConceptScore W2028779612C90924648 @default.
- W2028779612 hasIssue "2" @default.
- W2028779612 hasLocation W20287796121 @default.
- W2028779612 hasLocation W20287796122 @default.
- W2028779612 hasOpenAccess W2028779612 @default.
- W2028779612 hasPrimaryLocation W20287796121 @default.
- W2028779612 hasRelatedWork W1513667315 @default.
- W2028779612 hasRelatedWork W1981639878 @default.
- W2028779612 hasRelatedWork W2098196472 @default.
- W2028779612 hasRelatedWork W2134398282 @default.
- W2028779612 hasRelatedWork W2353103559 @default.
- W2028779612 hasRelatedWork W2376163507 @default.
- W2028779612 hasRelatedWork W3011454978 @default.
- W2028779612 hasRelatedWork W3197588893 @default.
- W2028779612 hasRelatedWork W4236584322 @default.
- W2028779612 hasRelatedWork W4362610586 @default.
- W2028779612 hasVolume "79" @default.
- W2028779612 isParatext "false" @default.
- W2028779612 isRetracted "false" @default.
- W2028779612 magId "2028779612" @default.
- W2028779612 workType "article" @default.