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- W2028779679 abstract "Neural plasticity requires protein synthesis, but the identity of newly synthesized proteins generated in response to plasticity-inducing stimuli remains unclear. We used in vivo bio-orthogonal noncanonical amino acid tagging (BONCAT) with the methionine analog azidohomoalanine (AHA) combined with the multidimensional protein identification technique (MudPIT) to identify proteins that are synthesized in the tadpole brain over 24 hr. We induced conditioning-dependent plasticity of visual avoidance behavior, which required N-methyl-D-aspartate (NMDA) and Ca(2+)-permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, αCaMKII, and rapid protein synthesis. Combining BONCAT with western blots revealed that proteins including αCaMKII, MEK1, CPEB, and GAD65 are synthesized during conditioning. Acute synthesis of CPEB during conditioning is required for behavioral plasticity as well as conditioning-induced synaptic and structural plasticity in the tectal circuit. We outline a signaling pathway that regulates protein-synthesis-dependent behavioral plasticity in intact animals, identify newly synthesized proteins induced by visual experience, and demonstrate a requirement for acute synthesis of CPEB in plasticity." @default.
- W2028779679 created "2016-06-24" @default.
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- W2028779679 date "2014-02-01" @default.
- W2028779679 modified "2023-10-11" @default.
- W2028779679 title "Acute Synthesis of CPEB Is Required for Plasticity of Visual Avoidance Behavior in Xenopus" @default.
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- W2028779679 doi "https://doi.org/10.1016/j.celrep.2014.01.024" @default.
- W2028779679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962200" @default.
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- W2028779679 hasPublicationYear "2014" @default.
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