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- W2028798277 abstract "Huperzine A (HupA), a naturally occurring alkaloid in the plant family Huperziaceae, has drawn great interest for its potential application in Alzheimer disease therapy. Our primary objective was to identify alkaloid- and HupA-producing fungi from the Chinese folk herb, Huperzia serrata. We established a rapid and efficient model for screening HupA-producing endophytic fungal strains. The presence of HupA in Paecilomyces tenuis YS-13 was analysed by thin-layer chromatography, high-performance liquid chromatography and mass spectrometry. The fermentation yield of HupA was 21.0 μg/L, and the IC50 of the crude extract of YS-13 fermentation broth was 1.27 ± 0.04 mg/mL. This is the first report of P. tenuis as a HupA-producing endophyte isolated from Huperziaceae." @default.
- W2028798277 created "2016-06-24" @default.
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- W2028798277 date "2014-11-27" @default.
- W2028798277 modified "2023-09-27" @default.
- W2028798277 title "Huperzine A production by<i>Paecilomyces tenuis</i>YS-13, an endophytic fungus isolated from<i>Huperzia serrata</i>" @default.
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- W2028798277 doi "https://doi.org/10.1080/14786419.2014.980245" @default.
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