FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028800710> ?p ?o ?g. }

• W2028800710 endingPage "211" @default.
• W2028800710 startingPage "203" @default.
• W2028800710 abstract "Refinement of the cell number by programmed cell death is a major morphogenetic mechanism of the developing central nervous system (CNS) in vertebrates including mammals, which determines to a significant degree its mature cytoarchitecture. We have examined the topography and the extent of cell death in different regions of the human CNS prenatally (11 fetuses), and in the early post-natal weeks (three newborns). Attention was focused on the wall of the telencephalon during a relatively short time period (12th-23rd week of gestation), corresponding to the time of major proliferation in the ventricular zone and to the peak of neuronal migration; both these mechanisms are crucial for corticogenesis. The TUNEL method was used, allowing the recognition of cell death because of its ability to label blunt ends of double-stranded DNA breaks. Morphological features of nuclei at different stages of apoptosis were identified, providing better evidence of the extent of the process than histological stains. Cell labelling was seen in either post-mitotic elements in the ventricular zone, or along the migratory pathways in the intermediate zone and subplate at all prenatal ages examined. No apoptotic nuclei were seen in the cortical plate. These findings suggest that apoptotic cell death drives the selection of cells which are committed to play a role during the early stages of corticogenesis. Lack of evidence of clonally related apoptotic cells also indicates that cell death occurs randomly. Therefore, molecular signals from the surrounding microenvironment seem to be necessary for the apoptotic pathway to be turned on, thus determining the fate of post-mitotic cells." @default.
• W2028800710 created "2016-06-24" @default.
• W2028800710 creator A5001920550 @default.
• W2028800710 creator A5017078229 @default.
• W2028800710 creator A5054732271 @default.
• W2028800710 date "1997-06-01" @default.
• W2028800710 modified "2023-10-16" @default.
• W2028800710 title "DNA fragmentation in normal development of the human central nervous system: a morphological study during corticogenesis" @default.
• W2028800710 cites W1587957817 @default.
• W2028800710 cites W1589415602 @default.
• W2028800710 cites W1651988031 @default.
• W2028800710 cites W1968776273 @default.
• W2028800710 cites W1973799912 @default.
• W2028800710 cites W1974436964 @default.
• W2028800710 cites W1982784171 @default.
• W2028800710 cites W1989759425 @default.
• W2028800710 cites W1990650378 @default.
• W2028800710 cites W1993902481 @default.
• W2028800710 cites W1995953333 @default.
• W2028800710 cites W2000269122 @default.
• W2028800710 cites W2005746771 @default.
• W2028800710 cites W2012055527 @default.
• W2028800710 cites W2012337697 @default.
• W2028800710 cites W2014348091 @default.
• W2028800710 cites W2022274052 @default.
• W2028800710 cites W2024077613 @default.
• W2028800710 cites W2025369435 @default.
• W2028800710 cites W2029737040 @default.
• W2028800710 cites W2034191611 @default.
• W2028800710 cites W2047552746 @default.
• W2028800710 cites W2050109791 @default.
• W2028800710 cites W2062539416 @default.
• W2028800710 cites W2070757813 @default.
• W2028800710 cites W2075761659 @default.
• W2028800710 cites W2077552569 @default.
• W2028800710 cites W2078458079 @default.
• W2028800710 cites W2081560586 @default.
• W2028800710 cites W2085162188 @default.
• W2028800710 cites W2091187793 @default.
• W2028800710 cites W2106352424 @default.
• W2028800710 cites W2114843411 @default.
• W2028800710 cites W2118785340 @default.
• W2028800710 cites W2130793535 @default.
• W2028800710 cites W2138302361 @default.
• W2028800710 cites W2490784244 @default.
• W2028800710 cites W4229704477 @default.
• W2028800710 cites W4238595262 @default.
• W2028800710 cites W4252929770 @default.
• W2028800710 doi "https://doi.org/10.1111/j.1365-2990.1997.tb01203.x" @default.
• W2028800710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9223129" @default.
• W2028800710 hasPublicationYear "1997" @default.
• W2028800710 type Work @default.
• W2028800710 sameAs 2028800710 @default.
• W2028800710 citedByCount "35" @default.
• W2028800710 countsByYear W20288007102012 @default.
• W2028800710 countsByYear W20288007102015 @default.
• W2028800710 countsByYear W20288007102016 @default.
• W2028800710 countsByYear W20288007102020 @default.
• W2028800710 crossrefType "journal-article" @default.
• W2028800710 hasAuthorship W2028800710A5001920550 @default.
• W2028800710 hasAuthorship W2028800710A5017078229 @default.
• W2028800710 hasAuthorship W2028800710A5054732271 @default.
• W2028800710 hasConcept C108619961 @default.
• W2028800710 hasConcept C142724271 @default.
• W2028800710 hasConcept C169760540 @default.
• W2028800710 hasConcept C18903297 @default.
• W2028800710 hasConcept C190283241 @default.
• W2028800710 hasConcept C191015642 @default.
• W2028800710 hasConcept C201750760 @default.
• W2028800710 hasConcept C28328180 @default.
• W2028800710 hasConcept C31573885 @default.
• W2028800710 hasConcept C43759708 @default.
• W2028800710 hasConcept C529278444 @default.
• W2028800710 hasConcept C533869091 @default.
• W2028800710 hasConcept C54355233 @default.
• W2028800710 hasConcept C71924100 @default.
• W2028800710 hasConcept C86803240 @default.
• W2028800710 hasConcept C95444343 @default.
• W2028800710 hasConceptScore W2028800710C108619961 @default.
• W2028800710 hasConceptScore W2028800710C142724271 @default.
• W2028800710 hasConceptScore W2028800710C169760540 @default.
• W2028800710 hasConceptScore W2028800710C18903297 @default.
• W2028800710 hasConceptScore W2028800710C190283241 @default.
• W2028800710 hasConceptScore W2028800710C191015642 @default.
• W2028800710 hasConceptScore W2028800710C201750760 @default.
• W2028800710 hasConceptScore W2028800710C28328180 @default.
• W2028800710 hasConceptScore W2028800710C31573885 @default.
• W2028800710 hasConceptScore W2028800710C43759708 @default.
• W2028800710 hasConceptScore W2028800710C529278444 @default.
• W2028800710 hasConceptScore W2028800710C533869091 @default.
• W2028800710 hasConceptScore W2028800710C54355233 @default.
• W2028800710 hasConceptScore W2028800710C71924100 @default.
• W2028800710 hasConceptScore W2028800710C86803240 @default.
• W2028800710 hasConceptScore W2028800710C95444343 @default.
• W2028800710 hasIssue "3" @default.
• W2028800710 hasLocation W20288007101 @default.
• W2028800710 hasLocation W20288007102 @default.
• W2028800710 hasOpenAccess W2028800710 @default.

• next