FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028807618> ?p ?o ?g. }

• W2028807618 endingPage "162" @default.
• W2028807618 startingPage "156" @default.
• W2028807618 abstract "CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis Aims: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin’s lymphoma, is clinically and pathologically heterogeneous. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas, and is considered to be an apoptosis-associated gene. CD10 is considered to be a marker of follicular centre B-cell differentiation. To assess the clinical significance and roles of CD10 and Bcl10 in DLBCL, we analysed 138 cases, using immunohistochemical methods. Methods and results: CD10 expression was limited to the cytoplasm, whereas Bcl10 expression was detected in the cytoplasm and/or nuclei. CD10 expression was detected in 39 of 138 cases (28.2%), cytoplasmic Bcl10 in 68 cases (49.2%), and nuclear Bcl10 in 34 cases (24.6%). Nuclear Bcl10 was detected in 14 of 28 cases (50%) of extranodal DLBCL, but only 20 of 110 cases (18.2%) of nodal DLBCL. Cytoplasmic Bcl10 was detected in 19 of 28 cases (67.8%) of extranodal DLBCL and 49 of 110 cases (44.5%) of nodal DLBCL. CD10 expression closely correlated with improved survival (68% overall survival (OS) vs. 48% OS), but not with site of disease. A high International Prognostic Index (IPI) was considered to be a poor prognostic factor associated with a shorter OS. CD10 expression was detected in 27 of 84 cases (32.1%) with low-risk IPIs, and in 12 of 54 cases (22.2%) with high-risk IPIs. In the low-risk group, cases expressing CD10 carried a better prognosis than CD10− cases (93% OS vs. 71% OS), whereas this was not the case in the high-risk group (25% vs. 20%). Conclusions: Bcl10 expression was associated with extranodal DLBCL, but not with prognosis. CD10 expression was closely associated with improved survival, but not with risk as predicted by IPI. Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL." @default.
• W2028807618 created "2016-06-24" @default.
• W2028807618 creator A5001399725 @default.
• W2028807618 creator A5041398079 @default.
• W2028807618 creator A5046638834 @default.
• W2028807618 creator A5048936597 @default.
• W2028807618 creator A5070398449 @default.
• W2028807618 creator A5082468164 @default.
• W2028807618 creator A5084066080 @default.
• W2028807618 creator A5086274287 @default.
• W2028807618 creator A5087097883 @default.
• W2028807618 date "2001-08-19" @default.
• W2028807618 modified "2023-09-25" @default.
• W2028807618 title "CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis" @default.
• W2028807618 cites W1563487810 @default.
• W2028807618 cites W1892527323 @default.
• W2028807618 cites W1977503403 @default.
• W2028807618 cites W1983826140 @default.
• W2028807618 cites W1987456705 @default.
• W2028807618 cites W1997640923 @default.
• W2028807618 cites W2006338784 @default.
• W2028807618 cites W2017249963 @default.
• W2028807618 cites W2029823192 @default.
• W2028807618 cites W2043008499 @default.
• W2028807618 cites W205637700 @default.
• W2028807618 cites W2073509625 @default.
• W2028807618 cites W2075696892 @default.
• W2028807618 cites W2107202569 @default.
• W2028807618 cites W2124872952 @default.
• W2028807618 cites W2147246240 @default.
• W2028807618 cites W2178535468 @default.
• W2028807618 cites W2276408020 @default.
• W2028807618 cites W2608724752 @default.
• W2028807618 cites W4205736005 @default.
• W2028807618 cites W4366064382 @default.
• W2028807618 doi "https://doi.org/10.1046/j.1365-2559.2001.01196.x" @default.
• W2028807618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11493332" @default.
• W2028807618 hasPublicationYear "2001" @default.
• W2028807618 type Work @default.
• W2028807618 sameAs 2028807618 @default.
• W2028807618 citedByCount "108" @default.
• W2028807618 countsByYear W20288076182012 @default.
• W2028807618 countsByYear W20288076182013 @default.
• W2028807618 countsByYear W20288076182014 @default.
• W2028807618 countsByYear W20288076182015 @default.
• W2028807618 countsByYear W20288076182016 @default.
• W2028807618 countsByYear W20288076182017 @default.
• W2028807618 countsByYear W20288076182019 @default.
• W2028807618 countsByYear W20288076182020 @default.
• W2028807618 countsByYear W20288076182021 @default.
• W2028807618 countsByYear W20288076182022 @default.
• W2028807618 countsByYear W20288076182023 @default.
• W2028807618 crossrefType "journal-article" @default.
• W2028807618 hasAuthorship W2028807618A5001399725 @default.
• W2028807618 hasAuthorship W2028807618A5041398079 @default.
• W2028807618 hasAuthorship W2028807618A5046638834 @default.
• W2028807618 hasAuthorship W2028807618A5048936597 @default.
• W2028807618 hasAuthorship W2028807618A5070398449 @default.
• W2028807618 hasAuthorship W2028807618A5082468164 @default.
• W2028807618 hasAuthorship W2028807618A5084066080 @default.
• W2028807618 hasAuthorship W2028807618A5086274287 @default.
• W2028807618 hasAuthorship W2028807618A5087097883 @default.
• W2028807618 hasConcept C107006841 @default.
• W2028807618 hasConcept C142724271 @default.
• W2028807618 hasConcept C159654299 @default.
• W2028807618 hasConcept C203014093 @default.
• W2028807618 hasConcept C204232928 @default.
• W2028807618 hasConcept C2777058707 @default.
• W2028807618 hasConcept C2778453870 @default.
• W2028807618 hasConcept C2778559949 @default.
• W2028807618 hasConcept C2779338263 @default.
• W2028807618 hasConcept C2779526237 @default.
• W2028807618 hasConcept C502942594 @default.
• W2028807618 hasConcept C71924100 @default.
• W2028807618 hasConcept C86803240 @default.
• W2028807618 hasConceptScore W2028807618C107006841 @default.
• W2028807618 hasConceptScore W2028807618C142724271 @default.
• W2028807618 hasConceptScore W2028807618C159654299 @default.
• W2028807618 hasConceptScore W2028807618C203014093 @default.
• W2028807618 hasConceptScore W2028807618C204232928 @default.
• W2028807618 hasConceptScore W2028807618C2777058707 @default.
• W2028807618 hasConceptScore W2028807618C2778453870 @default.
• W2028807618 hasConceptScore W2028807618C2778559949 @default.
• W2028807618 hasConceptScore W2028807618C2779338263 @default.
• W2028807618 hasConceptScore W2028807618C2779526237 @default.
• W2028807618 hasConceptScore W2028807618C502942594 @default.
• W2028807618 hasConceptScore W2028807618C71924100 @default.
• W2028807618 hasConceptScore W2028807618C86803240 @default.
• W2028807618 hasIssue "2" @default.
• W2028807618 hasLocation W20288076181 @default.
• W2028807618 hasLocation W20288076182 @default.
• W2028807618 hasOpenAccess W2028807618 @default.
• W2028807618 hasPrimaryLocation W20288076181 @default.
• W2028807618 hasRelatedWork W1501529729 @default.
• W2028807618 hasRelatedWork W1987784775 @default.
• W2028807618 hasRelatedWork W2028125597 @default.
• W2028807618 hasRelatedWork W2041703425 @default.
• W2028807618 hasRelatedWork W2044198452 @default.

• next