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• W2028829892 abstract "L-type Ca 2+ channels are broadly expressed in arterial smooth muscle cells, and their voltage-dependent properties are important in tone development. Recent studies have noted that these Ca 2+ channels are not singularly expressed in vascular tissue and that other subtypes are likely present. In this study, we ascertained which voltage-gated Ca 2+ channels are expressed in rat cerebral arterial smooth muscle and determined their contribution to the myogenic response. mRNA analysis revealed that the α 1 -subunit of L-type (Ca v 1.2) and T-type (Ca v 3.1 and Ca v 3.2) Ca 2+ channels are present in isolated smooth muscle cells. Western blot analysis subsequently confirmed protein expression in whole arteries. With the use of patch clamp electrophysiology, nifedipine-sensitive and -insensitive Ba 2+ currents were isolated and each were shown to retain electrical characteristics consistent with L- and T-type Ca 2+ channels. The nifedipine-insensitive Ba 2+ current was blocked by mibefradil, kurtoxin, and efonidpine, T-type Ca 2+ channel inhibitors. Pressure myography revealed that L-type Ca 2+ channel inhibition reduced tone at 20 and 80 mmHg, with the greatest effect at high pressure when the vessel is depolarized. In comparison, the effect of T-type Ca 2+ channel blockade on myogenic tone was more limited, with their greatest effect at low pressure where vessels are hyperpolarized. Blood flow modeling revealed that the vasomotor responses induced by T-type Ca 2+ blockade could alter arterial flow by ∼20–50%. Overall, our findings indicate that L- and T-type Ca 2+ channels are expressed in cerebral arterial smooth muscle and can be electrically isolated from one another. Both conductances contribute to myogenic tone, although their overall contribution is unequal." @default.
• W2028829892 created "2016-06-24" @default.
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• W2028829892 date "2013-01-01" @default.
• W2028829892 modified "2023-10-14" @default.
• W2028829892 title "Identification of L- and T-type Ca²⁺channels in rat cerebral arteries: role in myogenic tone development" @default.
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• W2028829892 doi "https://doi.org/10.1152/ajpheart.00476.2012" @default.
• W2028829892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3543679" @default.
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