FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028835160> ?p ?o ?g. }

• W2028835160 endingPage "8139" @default.
• W2028835160 startingPage "8128" @default.
• W2028835160 abstract "FGF-1 and FGF-2 are pleiotropic growth factors for many cell types, operating through the activation of specific transmembrane FGF receptors (FGFRs). The role of these factors in tumor progression was investigated, with specific discrimination between their autocrine and non autocrine cellular activity. The rat bladder carcinoma NBT-II cells were engineered to produce FGF-1 or 18 kDa FGF-2 in the presence or absence of their specific receptor. Non-autocrine cells that produced FGF-1 or FGF-2 but lacked FGFRs were epithelial and reminiscent of the parental NBT-II cells. Whilst autocrine cells, which both constitutively produced and secreted the growth factor and expressed FGFRs, had a highly invasive mesenchymal phenotype. Correspondingly, the autocrine cells were highly tumorigenic in vivo compared to the parental and non-autocrine cells, which correlated with the increased production of uPAR and active uPA and increased in vitro invasive potential. Although all cells produced VEGF, only tumors derived from cells that produced FGF-1 or FGF-2 were highly vascularized, suggesting that these two growth factors could be involved in the angiogenic process by activating host endothelial cells. As a result of activation of the FGFR in autocrine cells, changes in cell morphology and an increase in the invasive and tumorigenic properties were observed, however no in vitro or in vivo differential functions between FGF-1 and FGF-2 could be identified in this system. In conclusion, our data demonstrates that rapid tumor development is not dependent upon increased tumor vascularization, suggesting that 'basal' angiogenesis, probably mediated by VEGF, is sufficient to support tumor growth." @default.
• W2028835160 created "2016-06-24" @default.
• W2028835160 creator A5027814860 @default.
• W2028835160 creator A5030172426 @default.
• W2028835160 creator A5039283945 @default.
• W2028835160 creator A5091343254 @default.
• W2028835160 date "2002-11-19" @default.
• W2028835160 modified "2023-09-25" @default.
• W2028835160 title "Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2" @default.
• W2028835160 cites W105106768 @default.
• W2028835160 cites W1490533311 @default.
• W2028835160 cites W1545699847 @default.
• W2028835160 cites W1574172480 @default.
• W2028835160 cites W1854803455 @default.
• W2028835160 cites W1886431664 @default.
• W2028835160 cites W1969111387 @default.
• W2028835160 cites W1989228537 @default.
• W2028835160 cites W2005113904 @default.
• W2028835160 cites W2011151090 @default.
• W2028835160 cites W2013336992 @default.
• W2028835160 cites W2017448700 @default.
• W2028835160 cites W2027216690 @default.
• W2028835160 cites W2038101220 @default.
• W2028835160 cites W2039161118 @default.
• W2028835160 cites W2049087515 @default.
• W2028835160 cites W2055614600 @default.
• W2028835160 cites W2057896496 @default.
• W2028835160 cites W2058649124 @default.
• W2028835160 cites W2078187613 @default.
• W2028835160 cites W2079415755 @default.
• W2028835160 cites W2081309567 @default.
• W2028835160 cites W2083535354 @default.
• W2028835160 cites W2087848673 @default.
• W2028835160 cites W2088855481 @default.
• W2028835160 cites W2089798340 @default.
• W2028835160 cites W2091009027 @default.
• W2028835160 cites W2121164372 @default.
• W2028835160 cites W2127624074 @default.
• W2028835160 cites W2138178479 @default.
• W2028835160 cites W2144763197 @default.
• W2028835160 cites W2157338102 @default.
• W2028835160 cites W2168981489 @default.
• W2028835160 cites W2170134994 @default.
• W2028835160 cites W2323702574 @default.
• W2028835160 cites W2332835363 @default.
• W2028835160 cites W2334880322 @default.
• W2028835160 cites W4231316860 @default.
• W2028835160 cites W4361868714 @default.
• W2028835160 cites W1965225367 @default.
• W2028835160 doi "https://doi.org/10.1038/sj.onc.1205935" @default.
• W2028835160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12444548" @default.
• W2028835160 hasPublicationYear "2002" @default.
• W2028835160 type Work @default.
• W2028835160 sameAs 2028835160 @default.
• W2028835160 citedByCount "36" @default.
• W2028835160 countsByYear W20288351602013 @default.
• W2028835160 countsByYear W20288351602014 @default.
• W2028835160 countsByYear W20288351602015 @default.
• W2028835160 countsByYear W20288351602017 @default.
• W2028835160 countsByYear W20288351602018 @default.
• W2028835160 countsByYear W20288351602023 @default.
• W2028835160 crossrefType "journal-article" @default.
• W2028835160 hasAuthorship W2028835160A5027814860 @default.
• W2028835160 hasAuthorship W2028835160A5030172426 @default.
• W2028835160 hasAuthorship W2028835160A5039283945 @default.
• W2028835160 hasAuthorship W2028835160A5091343254 @default.
• W2028835160 hasBestOaLocation W20288351601 @default.
• W2028835160 hasConcept C128240485 @default.
• W2028835160 hasConcept C170493617 @default.
• W2028835160 hasConcept C2780394083 @default.
• W2028835160 hasConcept C502942594 @default.
• W2028835160 hasConcept C54355233 @default.
• W2028835160 hasConcept C55493867 @default.
• W2028835160 hasConcept C74373430 @default.
• W2028835160 hasConcept C7876069 @default.
• W2028835160 hasConcept C81885089 @default.
• W2028835160 hasConcept C86803240 @default.
• W2028835160 hasConcept C95444343 @default.
• W2028835160 hasConceptScore W2028835160C128240485 @default.
• W2028835160 hasConceptScore W2028835160C170493617 @default.
• W2028835160 hasConceptScore W2028835160C2780394083 @default.
• W2028835160 hasConceptScore W2028835160C502942594 @default.
• W2028835160 hasConceptScore W2028835160C54355233 @default.
• W2028835160 hasConceptScore W2028835160C55493867 @default.
• W2028835160 hasConceptScore W2028835160C74373430 @default.
• W2028835160 hasConceptScore W2028835160C7876069 @default.
• W2028835160 hasConceptScore W2028835160C81885089 @default.
• W2028835160 hasConceptScore W2028835160C86803240 @default.
• W2028835160 hasConceptScore W2028835160C95444343 @default.
• W2028835160 hasIssue "53" @default.
• W2028835160 hasLocation W20288351601 @default.
• W2028835160 hasLocation W20288351602 @default.
• W2028835160 hasOpenAccess W2028835160 @default.
• W2028835160 hasPrimaryLocation W20288351601 @default.
• W2028835160 hasRelatedWork W1979511416 @default.
• W2028835160 hasRelatedWork W2022171168 @default.
• W2028835160 hasRelatedWork W2030878664 @default.
• W2028835160 hasRelatedWork W2062435963 @default.

• next