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- W2028838686 abstract "CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight cancer. Besides agonistic antibodies the major way to stimulate death receptors is the use of their naturally occurring death ligands CD95L, TNF and TRAIL. However, dependent from the concept followed to develop a death ligand-based therapy various limiting aspects have to be taken into consideration on the way to a bedside usable drug. Problems arise in particular from the cell associated transmembrane nature of the death ligands, the poor serum half life of the soluble fragments derived from the transmembrane ligands, the ubiquitous expression of the death receptors and the existence of additional non-death receptors of the death ligands. Here, we summarize strategies how these limitations can be overcome by genetic engineering." @default.
- W2028838686 created "2016-06-24" @default.
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- W2028838686 date "2013-05-01" @default.
- W2028838686 modified "2023-09-27" @default.
- W2028838686 title "Engineering death receptor ligands for cancer therapy" @default.
- W2028838686 cites W1481859923 @default.
- W2028838686 cites W1484498750 @default.
- W2028838686 cites W1484817497 @default.
- W2028838686 cites W1578307296 @default.
- W2028838686 cites W174466561 @default.
- W2028838686 cites W1793898094 @default.
- W2028838686 cites W1834156694 @default.
- W2028838686 cites W1889350102 @default.
- W2028838686 cites W1892638662 @default.
- W2028838686 cites W1915374685 @default.
- W2028838686 cites W1967704552 @default.
- W2028838686 cites W1968295892 @default.
- W2028838686 cites W1968629782 @default.
- W2028838686 cites W1968844315 @default.
- W2028838686 cites W1969022613 @default.
- W2028838686 cites W1969876692 @default.
- W2028838686 cites W1971152363 @default.
- W2028838686 cites W1975291295 @default.
- W2028838686 cites W1980154450 @default.
- W2028838686 cites W1982875501 @default.
- W2028838686 cites W1986351221 @default.
- W2028838686 cites W1987145363 @default.
- W2028838686 cites W1988386148 @default.
- W2028838686 cites W1993898431 @default.
- W2028838686 cites W1997288872 @default.
- W2028838686 cites W2002915072 @default.
- W2028838686 cites W2007868209 @default.
- W2028838686 cites W2018631933 @default.
- W2028838686 cites W2020606836 @default.
- W2028838686 cites W2028705859 @default.
- W2028838686 cites W2031144635 @default.
- W2028838686 cites W2038780435 @default.
- W2028838686 cites W2038874598 @default.
- W2028838686 cites W2041623706 @default.
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- W2028838686 cites W2063228846 @default.
- W2028838686 cites W2068343030 @default.
- W2028838686 cites W2068960211 @default.
- W2028838686 cites W2069875612 @default.
- W2028838686 cites W2072380594 @default.
- W2028838686 cites W2082476235 @default.
- W2028838686 cites W2084733813 @default.
- W2028838686 cites W2086255604 @default.
- W2028838686 cites W2086940869 @default.
- W2028838686 cites W2087013919 @default.
- W2028838686 cites W2087366156 @default.
- W2028838686 cites W2089844883 @default.
- W2028838686 cites W2093052112 @default.
- W2028838686 cites W2098715950 @default.
- W2028838686 cites W2100019537 @default.
- W2028838686 cites W2100078626 @default.
- W2028838686 cites W2105860664 @default.
- W2028838686 cites W2113837827 @default.
- W2028838686 cites W2116039167 @default.
- W2028838686 cites W2118971842 @default.
- W2028838686 cites W2121391223 @default.
- W2028838686 cites W2122090671 @default.
- W2028838686 cites W2122711939 @default.
- W2028838686 cites W2124332120 @default.
- W2028838686 cites W2125560522 @default.
- W2028838686 cites W2135640361 @default.
- W2028838686 cites W2144430905 @default.
- W2028838686 cites W2144580269 @default.
- W2028838686 cites W2148692770 @default.
- W2028838686 cites W2163235485 @default.
- W2028838686 cites W2168816648 @default.
- W2028838686 cites W2313110713 @default.
- W2028838686 cites W2316527245 @default.
- W2028838686 cites W2327001242 @default.
- W2028838686 cites W4229724440 @default.
- W2028838686 doi "https://doi.org/10.1016/j.canlet.2010.12.019" @default.
- W2028838686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21236560" @default.
- W2028838686 hasPublicationYear "2013" @default.
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