FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028841212> ?p ?o ?g. }

• W2028841212 endingPage "307" @default.
• W2028841212 startingPage "293" @default.
• W2028841212 abstract "In this study of the developing human hippocampus, we monitor the timing of onset and the sequential patterns of expression of 11 developmentally regulated proteins that are important components of the neuronal cytoskeleton. Immunohistochemistry using well-characterized antibodies was conducted with fixed paraffin-embedded sections from hippocampi at various stages of fetal and postnatal development. At 9 weeks gestational age, immunoreactivity was evident for the microtubule-associated proteins (MAPs), MAP2 and MAP5, low molecular weight (Mr) neurofilament (NF) protein (NF-L), poorly phosphorylated mid-Mr NF protein (NF-M/P-), vimentin, and alpha-and beta-tubulins within the somatodendritic domain of neurons of the hippocampal plate. Weak immunoreactivity for moderately phosphorylated, high Mr NF protein (NF-H/P + + +), tau, and nestin was observed. Highly phosphorylated mid-Mr NF protein (NF-M/P + + +) and alpha-internexin were first detected at 15 weeks and highly phosphorylated, high Mr NF protein (NF-H/P+3) at 20 weeks. At 15 weeks, MAP2, MAP5, and tubulins were expressed in an inside-out gradient and in a gradient between hippocampal subfields with subiculum > ammonic subfields > dentate gyrus. These gradients paralleled the maturational gradients seen in cytoarchitectural and neuronal morphologic studies. The adult pattern of neuronal cytoskeletal protein expression in the hippocampus was attained by the second postnatal year for all proteins. Our findings demonstrate an elaborate orchestration of cytoskeletal protein expression within the hippocampus that is qualitatively similar to what is seen in other brain regions and in nonhuman species but which also has some important differences in timing and pattern. The differences in the developmentally regulated expression of neuronal cytoskeletal proteins in separate regions of the central nervous system (CNS) suggest that there are region-specific differences in composition and function of the neuronal cytoskeleton. These observations have implications for understanding the role of the neuronal cytoskeleton in the developing, mature, and diseased CNS." @default.
• W2028841212 created "2016-06-24" @default.
• W2028841212 creator A5021394368 @default.
• W2028841212 creator A5088881304 @default.
• W2028841212 date "1996-04-01" @default.
• W2028841212 modified "2023-10-14" @default.
• W2028841212 title "Human fetal hippocampal development: II. The neuronal cytoskeleton" @default.
• W2028841212 cites W1249861899 @default.
• W2028841212 cites W1482198038 @default.
• W2028841212 cites W1490772092 @default.
• W2028841212 cites W1554920990 @default.
• W2028841212 cites W1562270612 @default.
• W2028841212 cites W1576914487 @default.
• W2028841212 cites W1585713390 @default.
• W2028841212 cites W1601155059 @default.
• W2028841212 cites W1814239271 @default.
• W2028841212 cites W1953832287 @default.
• W2028841212 cites W1964904696 @default.
• W2028841212 cites W1965232330 @default.
• W2028841212 cites W1965514530 @default.
• W2028841212 cites W1965930232 @default.
• W2028841212 cites W1966614543 @default.
• W2028841212 cites W1967024359 @default.
• W2028841212 cites W1967132848 @default.
• W2028841212 cites W1971696611 @default.
• W2028841212 cites W1972308707 @default.
• W2028841212 cites W1973774127 @default.
• W2028841212 cites W1988101736 @default.
• W2028841212 cites W1992526188 @default.
• W2028841212 cites W1996322041 @default.
• W2028841212 cites W1996542144 @default.
• W2028841212 cites W1998298207 @default.
• W2028841212 cites W2001486260 @default.
• W2028841212 cites W2006875343 @default.
• W2028841212 cites W2007824057 @default.
• W2028841212 cites W2023675720 @default.
• W2028841212 cites W2023930700 @default.
• W2028841212 cites W2026570198 @default.
• W2028841212 cites W2029923284 @default.
• W2028841212 cites W2034191611 @default.
• W2028841212 cites W2038708976 @default.
• W2028841212 cites W2038910860 @default.
• W2028841212 cites W2042458678 @default.
• W2028841212 cites W2044776028 @default.
• W2028841212 cites W2047964353 @default.
• W2028841212 cites W2056501413 @default.
• W2028841212 cites W2060792213 @default.
• W2028841212 cites W2066052286 @default.
• W2028841212 cites W2067646093 @default.
• W2028841212 cites W2069826560 @default.
• W2028841212 cites W2074285696 @default.
• W2028841212 cites W2080557519 @default.
• W2028841212 cites W2087490798 @default.
• W2028841212 cites W2101356420 @default.
• W2028841212 cites W2104429436 @default.
• W2028841212 cites W2116897930 @default.
• W2028841212 cites W2117198101 @default.
• W2028841212 cites W2125763225 @default.
• W2028841212 cites W2131518907 @default.
• W2028841212 cites W2171602378 @default.
• W2028841212 cites W2173145139 @default.
• W2028841212 cites W2330135994 @default.
• W2028841212 cites W2400688595 @default.
• W2028841212 cites W2484638570 @default.
• W2028841212 cites W4256350582 @default.
• W2028841212 cites W4317563449 @default.
• W2028841212 cites W565375828 @default.
• W2028841212 doi "https://doi.org/10.1002/(sici)1096-9861(19960401)367:2<293::aid-cne10>3.0.co;2-s" @default.
• W2028841212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8708011" @default.
• W2028841212 hasPublicationYear "1996" @default.
• W2028841212 type Work @default.
• W2028841212 sameAs 2028841212 @default.
• W2028841212 citedByCount "80" @default.
• W2028841212 countsByYear W20288412122012 @default.
• W2028841212 countsByYear W20288412122013 @default.
• W2028841212 countsByYear W20288412122014 @default.
• W2028841212 countsByYear W20288412122016 @default.
• W2028841212 countsByYear W20288412122017 @default.
• W2028841212 countsByYear W20288412122018 @default.
• W2028841212 countsByYear W20288412122019 @default.
• W2028841212 countsByYear W20288412122020 @default.
• W2028841212 countsByYear W20288412122021 @default.
• W2028841212 countsByYear W20288412122022 @default.
• W2028841212 countsByYear W20288412122023 @default.
• W2028841212 crossrefType "journal-article" @default.
• W2028841212 hasAuthorship W2028841212A5021394368 @default.
• W2028841212 hasAuthorship W2028841212A5088881304 @default.
• W2028841212 hasConcept C11960822 @default.
• W2028841212 hasConcept C142669718 @default.
• W2028841212 hasConcept C147447768 @default.
• W2028841212 hasConcept C148762608 @default.
• W2028841212 hasConcept C1491633281 @default.
• W2028841212 hasConcept C157207234 @default.
• W2028841212 hasConcept C169760540 @default.
• W2028841212 hasConcept C203014093 @default.
• W2028841212 hasConcept C204232928 @default.
• W2028841212 hasConcept C2776464000 @default.
• W2028841212 hasConcept C2778499278 @default.

• next