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- W2028841658 abstract "Both of the geometric isomers of clomiphene cause an increase in the desmosterol content of tissues of rats receiving the compounds by gastric route for 10 days; these results indicate inhibition in vivo of sterol Δ24-reductase. The trans isomer is approximately 10 times as potent as the cis isomer as an inhibitor of this enzyme. Both were less potent than triparanol. Trans-clomiphene reduced the total sterol content of plasma, adrenal and ovary more than did cis-clomiphene or triparanol (dose range, 1–10 mg/kg); it therefore has an effect on sterol metabolism in the rat additional to its effect on Δ24-reductase. The desmosterol data demonstrate the importance of steric configuration of the triphenylethyl portion of the clomiphene molecule as a determinant of potency of Δ24-reductase inhibition. A mechanism is postulated for inhibition of Δ24-reductase by known inhibitors, involving interaction of the amino nitrogen of the inhibitor with an electrophilic group at the enzyme active site." @default.
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- W2028841658 date "1970-07-01" @default.
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- W2028841658 title "Effects of clomiphene cis and trans isomers on sterol metabolism in the rat" @default.
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- W2028841658 doi "https://doi.org/10.1016/0006-2952(70)90122-x" @default.
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