FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028842146> ?p ?o ?g. }

• W2028842146 endingPage "1874" @default.
• W2028842146 startingPage "1866" @default.
• W2028842146 abstract "Glomerular monocytes predict worse outcomes after acute renal allograft rejection independent of C4d status.BackgroundBoth peritubular capillary (PTC) C4d deposition and macrophage/monocyte (MO) infiltration in acute rejection (AR) have separately been shown to be associated with reduced graft survival and recently were demonstrated to be closely correlated in AR. Whether MO infiltration is an independent predictor of graft outcome is uncertain.MethodsAll patients with biopsy-proven AR (over a 3-year period) were included (N = 96). All biopsies (N = 121) were graded according to the Banff 97 criteria and immunohistochemically stained for C4d and MO (CD68). The primary outcome was glomerular filtration rate (GFR) <30 mL/min 1-year posttransplant as estimated by the Modified Diet in Renal Disease (MDRD) Formula. Secondary outcomes at 2 and 4 years' posttransplant were also explored. A variety of clinical and biopsy variables were statistically analyzed to establish univariate predictors of graft outcome. Stepwise multivariate logistic regression modeling was applied to determine independent predictors of outcomes.ResultsThere was a close correlation between PTC C4d and glomerular MO infiltration (P < 0.001). Univariate predictors of primary outcome (GFR <30 mL/min 1-year posttransplant) included mean glomerular MO count ≥1.0 MO/glomerulus (P = 0.014), female sex (P = 0.02), higher peak (P = 0.005), and pretransplant (P = 0.003) panel-reactive antibody levels, cadaveric donor (P = 0.006), transplant glomerulitis (P = 0.004), and longer cold ischemic time (CIT) (P = 0.002). Mean MO/glomerulus ≥1.0 [OR 10.3 (1.23, 87.1)], female sex [OR 5.27(1.31, 21.1)], and CIT [OR 1.14 (1.06, 1.25)] were identified as independent predictors of adverse graft outcome. Furthermore, mean MO/glomerulus ≥1.0 independently predicted poor renal function at 2 years [OR 3.89 (1.19, 12.70)] and 4 years [OR 4.03 (1.22, 13.28)] posttransplant.ConclusionThe results demonstrate that glomerular MO infiltration is an independent predictor of worse outcomes posttransplant following acute renal allograft rejection. Glomerular monocytes predict worse outcomes after acute renal allograft rejection independent of C4d status. Both peritubular capillary (PTC) C4d deposition and macrophage/monocyte (MO) infiltration in acute rejection (AR) have separately been shown to be associated with reduced graft survival and recently were demonstrated to be closely correlated in AR. Whether MO infiltration is an independent predictor of graft outcome is uncertain. All patients with biopsy-proven AR (over a 3-year period) were included (N = 96). All biopsies (N = 121) were graded according to the Banff 97 criteria and immunohistochemically stained for C4d and MO (CD68). The primary outcome was glomerular filtration rate (GFR) <30 mL/min 1-year posttransplant as estimated by the Modified Diet in Renal Disease (MDRD) Formula. Secondary outcomes at 2 and 4 years' posttransplant were also explored. A variety of clinical and biopsy variables were statistically analyzed to establish univariate predictors of graft outcome. Stepwise multivariate logistic regression modeling was applied to determine independent predictors of outcomes. There was a close correlation between PTC C4d and glomerular MO infiltration (P < 0.001). Univariate predictors of primary outcome (GFR <30 mL/min 1-year posttransplant) included mean glomerular MO count ≥1.0 MO/glomerulus (P = 0.014), female sex (P = 0.02), higher peak (P = 0.005), and pretransplant (P = 0.003) panel-reactive antibody levels, cadaveric donor (P = 0.006), transplant glomerulitis (P = 0.004), and longer cold ischemic time (CIT) (P = 0.002). Mean MO/glomerulus ≥1.0 [OR 10.3 (1.23, 87.1)], female sex [OR 5.27(1.31, 21.1)], and CIT [OR 1.14 (1.06, 1.25)] were identified as independent predictors of adverse graft outcome. Furthermore, mean MO/glomerulus ≥1.0 independently predicted poor renal function at 2 years [OR 3.89 (1.19, 12.70)] and 4 years [OR 4.03 (1.22, 13.28)] posttransplant. The results demonstrate that glomerular MO infiltration is an independent predictor of worse outcomes posttransplant following acute renal allograft rejection." @default.
• W2028842146 created "2016-06-24" @default.
• W2028842146 creator A5032482746 @default.
• W2028842146 creator A5063266999 @default.
• W2028842146 creator A5064535437 @default.
• W2028842146 date "2005-10-01" @default.
• W2028842146 modified "2023-09-25" @default.
• W2028842146 title "Glomerular monocytes predict worse outcomes after acute renal allograft rejection independent of C4d status" @default.
• W2028842146 cites W1906278494 @default.
• W2028842146 cites W1964465727 @default.
• W2028842146 cites W1980073060 @default.
• W2028842146 cites W1992580742 @default.
• W2028842146 cites W1995791071 @default.
• W2028842146 cites W1999198142 @default.
• W2028842146 cites W2015289718 @default.
• W2028842146 cites W2023351642 @default.
• W2028842146 cites W2039561258 @default.
• W2028842146 cites W2053465471 @default.
• W2028842146 cites W2053797842 @default.
• W2028842146 cites W2055864845 @default.
• W2028842146 cites W2060508116 @default.
• W2028842146 cites W2065749193 @default.
• W2028842146 cites W2073486682 @default.
• W2028842146 cites W2075747578 @default.
• W2028842146 cites W2076119008 @default.
• W2028842146 cites W2078304474 @default.
• W2028842146 cites W2078305327 @default.
• W2028842146 cites W2081909757 @default.
• W2028842146 cites W2090173675 @default.
• W2028842146 cites W2096600563 @default.
• W2028842146 cites W2100428481 @default.
• W2028842146 cites W2105526160 @default.
• W2028842146 cites W2115045605 @default.
• W2028842146 cites W2116357080 @default.
• W2028842146 cites W2117127436 @default.
• W2028842146 cites W2118493727 @default.
• W2028842146 cites W2122083735 @default.
• W2028842146 cites W2125297646 @default.
• W2028842146 cites W2164993846 @default.
• W2028842146 cites W2168735100 @default.
• W2028842146 cites W2315888271 @default.
• W2028842146 cites W2331830314 @default.
• W2028842146 cites W4296899486 @default.
• W2028842146 doi "https://doi.org/10.1111/j.1523-1755.2005.00606.x" @default.
• W2028842146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16164665" @default.
• W2028842146 hasPublicationYear "2005" @default.
• W2028842146 type Work @default.
• W2028842146 sameAs 2028842146 @default.
• W2028842146 citedByCount "122" @default.
• W2028842146 countsByYear W20288421462012 @default.
• W2028842146 countsByYear W20288421462013 @default.
• W2028842146 countsByYear W20288421462014 @default.
• W2028842146 countsByYear W20288421462015 @default.
• W2028842146 countsByYear W20288421462016 @default.
• W2028842146 countsByYear W20288421462017 @default.
• W2028842146 countsByYear W20288421462018 @default.
• W2028842146 countsByYear W20288421462019 @default.
• W2028842146 countsByYear W20288421462020 @default.
• W2028842146 countsByYear W20288421462021 @default.
• W2028842146 countsByYear W20288421462022 @default.
• W2028842146 countsByYear W20288421462023 @default.
• W2028842146 crossrefType "journal-article" @default.
• W2028842146 hasAuthorship W2028842146A5032482746 @default.
• W2028842146 hasAuthorship W2028842146A5063266999 @default.
• W2028842146 hasAuthorship W2028842146A5064535437 @default.
• W2028842146 hasBestOaLocation W20288421461 @default.
• W2028842146 hasConcept C126322002 @default.
• W2028842146 hasConcept C126894567 @default.
• W2028842146 hasConcept C142724271 @default.
• W2028842146 hasConcept C144301174 @default.
• W2028842146 hasConcept C151956035 @default.
• W2028842146 hasConcept C159641895 @default.
• W2028842146 hasConcept C204232928 @default.
• W2028842146 hasConcept C2775934546 @default.
• W2028842146 hasConcept C2776460901 @default.
• W2028842146 hasConcept C2778653478 @default.
• W2028842146 hasConcept C2780303639 @default.
• W2028842146 hasConcept C2780306776 @default.
• W2028842146 hasConcept C2781087799 @default.
• W2028842146 hasConcept C2911091166 @default.
• W2028842146 hasConcept C38180746 @default.
• W2028842146 hasConcept C71924100 @default.
• W2028842146 hasConcept C90924648 @default.
• W2028842146 hasConceptScore W2028842146C126322002 @default.
• W2028842146 hasConceptScore W2028842146C126894567 @default.
• W2028842146 hasConceptScore W2028842146C142724271 @default.
• W2028842146 hasConceptScore W2028842146C144301174 @default.
• W2028842146 hasConceptScore W2028842146C151956035 @default.
• W2028842146 hasConceptScore W2028842146C159641895 @default.
• W2028842146 hasConceptScore W2028842146C204232928 @default.
• W2028842146 hasConceptScore W2028842146C2775934546 @default.
• W2028842146 hasConceptScore W2028842146C2776460901 @default.
• W2028842146 hasConceptScore W2028842146C2778653478 @default.
• W2028842146 hasConceptScore W2028842146C2780303639 @default.
• W2028842146 hasConceptScore W2028842146C2780306776 @default.
• W2028842146 hasConceptScore W2028842146C2781087799 @default.
• W2028842146 hasConceptScore W2028842146C2911091166 @default.
• W2028842146 hasConceptScore W2028842146C38180746 @default.

• next